PLENARY / SPECIAL LECTURES
1947-55 Emanuel School, London (A levels in Chemistry, Physics, Botany & Zoology)
1955-1958 University College London. BSc (1st Class honours) 1958. Class Prize in Physiology.
1958-1961. Bayliss-Starling Scholar, University College London.
1961 PhD Supervisor: O.F.Hutter (later Regius Professor of Physiology in Glasgow).
1961—1963. Assistant Lecturer in Physiology, University College London.
1961—1963. Vice-Warden of Connaught Hall (University of London).
1963—1984. Fellow and Tutor, Balliol College, Oxford. University Lecturer in Physiology.
1969—1970. Visiting Professor and Visiting Scientist of the Canadian MRC.
1971—1989. Head (Praefectus) of the Balliol College Graduate Centre at Holywell Manor
1975—1985 Leader of MRC Programme Grant team.
1983—1985. Vice-Master of Balliol College
1984—2004 Burdon Sanderson Professor of Cardiovascular Physiology, Oxford University
1984—2004 Professorial Fellow, Balliol College.
2004-now Emeritus Professor of Cardiovascular Physiology, Oxford University
2004-now Emeritus Fellow of Balliol College, Oxford
2004-now Director of Computational Physiology, Co-Director of e-science centre, Oxford.
2003-2007 Adjunct Professor Xi’an Jiaotong University, Shaanxi province, China
2005-now Visiting Professor, Osaka University, Japan
1984-now Chairman and Director, Oxsoft Ltd
1994-2003 Founder and Director, Physiome Sciences Inc
1967-now Chief Editor, Progress in Biophysics and Molecular Biology
2001-2005 International Advisor, Tsinghua Science and technology
2004-2006 Chief Editor, Drug Discovery Today: Disease Models
2004-2006 Editorial Board, Transactions on Computational Systems Biology
2004-2007 Advisor to Board of Journal of Experimental Physiology
2005-2020 Chief Editor, Faculty of 1000, Physiology
2011-2017 Editor, Interface Focus
1993-2001 Secretary-General of International Union of Physiological Sciences (IUPS)
2001-now Membre du Jury, Prix Lefoulon-Delalande, Academie des Sciences, Paris
2009-2017 President of the International Union of Physiological Sciences (IUPS)
1994-2004 Member of government Advisory Group on Korea (DTI)
1986-2006 Executive Committee of Campaign for Science and Engineering (UK)
Main Previous Committees
MRC (former Chairman of Joint Dental Committee 1984-1990)
Member of Advisory Group on non-ionizing radiation (AGNIR), Health Protection Agency (HPA).
Royal Society Committees
Member of Council, Oxford University 1989-2004
Member of Systems Biology Committee, Academy of Medical Sciences and Academy of Engineering
Systems Panel of BBSRC
ARTICLES. Over 600 articles in academic journals, including Nature, Science, PNAS, Journal of
Physiology, Progress in Biophysics & Molecular Biology Listed on Google Scholar:
Many articles in national press
Author or Editor of 13 books, including
The Initiation of the Heartbeat (OUP, 1975, 1979 and Japanese translation), sole author
Electric Current Flow in Excitable Cells (OUP 1975, 1988), author with JJB Jack and RW Tsien
The Logic of Life (OUP 1993), co-editor with CAR Boyd, and author
The Ethics of Life (UNESCO 1997) co-editor with J-D Vincent
The Music of Life (OUP 2006) sole author
La Musique de la Vie (Editions du Seuil, 2007 – French edition of The Music of Life))
La Musica de la Vida (Akal, 2008 – Spanish edition of The Music of Life))
La Musica della Vita (Bollati-Boringhieri, 2008 – Italian edition of The Music of Life)
⽣命の⾳楽：ゲノムを越える⽣物学 (Japanese edition of The Music of Life, 2009)
!"# $% (Korean edition of The Music of Life – Open Science, 2009)
⽣命的乐章 (Chinese edition of The Music of Life – 2010)
The Selected papers of Denis Noble CBE FRS. A journey in physiology toward enlightenment. Imperial
College Press 2012
Dance to the Tune of Life: Biological Relativity (CUP) 2016
The Language of Symmetry, Routledge. 2023
Dance to the Tune of Life (Japanese Translation) 2023
Understanding Living Systems, (with Raymond Noble), Cambridge University Press 2023
Honours and awards
1970 Scientific Medal of the Zoological Society.
1979 Elected Fellow of the Royal Society (FRS).
1982 Research Fellowship for Academic Staff (Medical Research Council).
1985 British Heart Foundation's biennial Gold Medal and Prize.
1985 Correspondant Etranger de l'Académie Royale de Médecine de Belgique.
1986 Fellow of University College London.
1988 Honorary Member of the Royal College of Physicians (Hon MRCP).
1989 Member of Academia Europaea
1989 Professorial Distinction Award, Oxford University
1991 Pierre Rijlant Prize (l'Académie Royale de Médecine de Belgique).
1993 Baly Medal of the Royal College of Physicians (London).
1993 Honorary Foreign Member of the Académie Royale de Médecine de Belgique.
1994 Honorary Fellow of the Royal College of Physicians (Hon FRCP)
1996 Honorary Member of the American Physiological Society
1997 Honorary Member of the Physiological Society (UK & Ireland)
1998 Honorary Member of the Physiological Society of Japan
1998 Appointed CBE in Queen’s Birthday Honours List, for ‘services to science’
1998 Visiting Professor at Johns Hopkins University, Baltimore, USA
1999 Founding Fellow of the Academy of Medical Science (FMedSci)
2000 Founding Fellow of the International Society for Heart Research
2001 Honorary Fellowship of the Institute of Physics and Engineering in Medicine
2003 Appointed Adjunct Professor Xi’an Jiaotong University, Shaanxi province, China (2003-2007)
2004 Honorary Degree of Doctor of Science by Sheffield University
2004 Awarded Russian Academy of Sciences Pavlov Medal at Russian Physiological Society Congress
2004 Hodgkin-Huxley-Katz Prize, The Physiological Society (UK)
2005 MacKenzie Prize, British Cardiac Society, May 2005
2005 Docteur Honoris Causa, Université de Bordeaux, September 2005
2008 Medal of Merit, EU-ISHR, Athens, May 2008
2008 Honorary Degree of Doctor of Science University of Warwick, July 2008
2010 Member of Slovenian Academy of Science
2012 Collaborative Professor, Osaka University, Japan
2013 Membro Straniero, Istituto Lombardo-Accademia di Scienze e Lettere
2022 Awarded Lomonosov Grand Gold Medal by the Russian Academy of Sciences
Named invited Lectures
1962 Invited Lecture, IUPS Congress, Leiden
1966. Darwin Lecture, British Association.
1977. Nahum Lecture, Yale University.
1977. Invited review lecture. IUPS Congress. Paris (delivered in French).
1979. Conférence invitée. Association des Physiologistes. (Delivered and published in French)
1981. Waller Lecture, London University
1983. Annual Review Lecture. The Physiological Society. (Published as The Surprising Heart)
1984. Withering Memorial Lecture. International Congress of Pharmacology. London
1985. Lettura F. Botazzi. Società Italiana di Fisiologia. Pisa. (Delivered in Italian).
1985. Ueda Lecture. Japanese Society of Electrocardiologists. Tokyo. (given partly in Japanese)
1987. Lloyd-Roberts Lecture, Royal Society of Medicine, London
1988. Allerdale-Wyld Memorial Lecture – Northern Industrial Societies.
1988. Bowden Lecture – University of Manchester Institute of Science and Technology
1989. Bacaner Research Awards lecture, University of Minnesota.
1989. Distinguished visiting lecturer at the Universities of British Columbia, Alberta and Calgary.
1989. Distinguished visiting professor at the State University of New York at Stony Brook, USA.
1990. Oliver Sharpey Lecture --- The Royal College of Physicians, London.
1990. Butland Visiting Professor at the University of Auckland, New Zealand.
1990. Annual Review Lecture, Korean Physiological Society (delivered partly in Korean).
1991. Invited lecturer at the 150th anniversary celebrations of the Académie Royale de Médecine de
Belgique, Brussels. (delivered in French)
1993. Annual Foundation Lecture of International Science Policy Foundation.
1994. First triennial Rijlant Lecture to International Congress of Electrocardiology (Japan).
1995. First annual lecture at UCL on disabled students in higher education.
1996. Frank May Public Lecture, Leicester University.
1996. Conference Claude Bernard, Societé de Physiologie, Lille, (delivered in French)
1996. Stevenson lecture, University of Western Ontario.
2003. Magnes Lecture, Hebrew University of Jerusalem and Israeli Physiological Society.
2003. Larmor Lecture, Queen’s University, Belfast.
2004. Conway Lecture, University College Dublin.
2004. Hodgkin-Huxley-Katz Prize Lecture, The Physiological Society.
2006. Woolmer Lecture, Institute of Physics and Engineering in Medicine, Cambridge 6 September
2006. Plenary Lecture, FAOPS Congress, Seoul, October
2007. Jacques Morgenstern Colloquium, INRIA Sophia-Antipolis
2007. Paton Lecture, The Physiological Society
2007. McDowall Lecture, King’s College London
2007 Distinguished Invited Lecture, EMBL Heidelberg
2008 Public Lecture, Museum of the History of Science, Oxford
2008 George Cecil Clarke Lecture, Nottingham University
2009 Foster Lecture, Cambridge University
2009 Kroto Lecture, Sheffield University
2010 Moe Lecture, Chicago
2012. Rupert Riedl Lecture, Vienna
2012. Plenary Lecture, Chinese Association of Physiological Sciences, Suzhou.
2013. President’s Lecture, IUPS, Birmingham
2013. Lecture to Istituto Lombardo, Milan (delivered in Italian)
Many other Congress and Symposia Plenary lectures. Denis Noble gives about many public invited
lectures per year in Universities, Congresses, Foundations and Societies worldwide.
2003-2008 EPSRC eScience Pilot Project in Integrative Biology £2,798,950 (PI on interdisciplinary
Wellcome Trust Cardiac Physiome programme grant £1.2 million
EU 6th Framework Programme, 2004-2009, Biosimulation network Euros 300,000 2004-2009.
EU 7th Framework Programme PreDiCT 2008-2011 approx 4 million euros
EU 7th Framework Programme Virtual Human Network of Excellence. 2008-2013 approx 8 million
euros, part of Oxford led ICT grants totally 27 million euros.
British Heart Foundation, about £100,000
2013-2018 University of Oxford Innovative Systems Biology Project funded by Tsumura, £2million
The Physiological Society
(Hon Secretary 1974—80; Foreign Secretary 1986—92; Honorary Member 1997)).
The Royal Society (Member of various committees).
The Royal College of Physicians (Honorary Fellow)
British Biophysical Society (past member of Committee)
British Cardiac Society
Académie Royale de Médecine de Belgique
Academia Europaea (past Convenor in Physiology and Biophysics)
CaSE, (Campaign for Science and Engineering founded as Save British Science, Founder and member
of Executive Committee)
American Physiological Society (Honorary Member 1996)
International Union of Physiological Sciences (IUPS) (Secretary-General, 1994—2001, President
Japan Physiological Society (Honorary Member, 1998)
Academy of Medical Sciences (Founder Fellow, 1998)
International Society for Heart Research (Founding Fellow 2000)
Institute of Physics and Engineering in Medicine (Honorary Fellow)
Fellow, The Linnean Society of London, 2021.
Russian Academy of Sciences, Foreign Member 2022
Other interests and activities
Philosophy Publications in professional journals of philosophy, and books. See
Cooking French & Indian
Classical Guitar: player and owner of Rubio, Ramirez and Fischer guitars.
For music see website https://www.denisnoble.com/music/
French – very highly fluent, able to give lectures and interviews without notes. Denis Noble was a
member of the Committee of the Maison Française d’Oxford and has broadcast frequently in France.
Italian – sufficient to give prepared lectures in Italian.
Occitan – Good knowledge of most dialects and speaker of Limousin; Denis Noble has appeared on
French Radio concerning Occitan language and music and has contributed to Occitan publications. He
is founder of The Oxford Trobadors, who interpret Occitan songs, medieval and modern.
Catalan, good reading ability
Portuguese, Good reading ability
Japanese – good knowledge of spoken and written language (including Kanji), sufficient to write and
deliver prepared speeches and short lectures in Japanese. Several publications in Japanese.
Korean – good knowledge of written Korean (Hangul) and some knowledge of Chinese script
(Hancha). Sufficient knowledge of spoken Korean to give a speech or introduction to a lecture. Denis
Noble was a UK Government Advisor on Korea.
Chinese – some reading knowledge (through Japanese and Korean characters, and study of medieval
Chinese medical texts)
Maori – delivered the reply to the Maori welcome (Powhiri) at the IUPS Congress in Christchurch,
New Zealand, 2001.
Others – some knowledge of many other languages (Denis Noble makes it a rule to learn something of
the language in any country he visits)
Citation statistics on google scholar: http://scholar.google.co.uk/citations?
Martin Morad, PhD. is Professor of Regenerative Medicine and Cell Biology at the Medical University of South Carolina (MUSC) and the University of South Carolina (USC) and Professor of Bioengineering at Clemson University. He is the Director of the Cardiac Signaling Center and holds the BlueCross Blue Shield of South Carolina Endowed Chair in Cardiovascular Health, which includes a unique three-way faculty appointment at the USC, MUSC and Clemson University.
Dr. Morad is an internationally recognized scientist in the field of cardiac electrophysiology and calcium signaling. He has pioneered many of the seminal findings and technology in the field of Cardiac calcium signaling. He has had over 300 original publications, 20 of which have appeared in Science and Nature. Dr. Morad’s career is marked by an incessant drive to formulate new physiological and molecular concepts based on innovative technology. He was first to Voltage-clamp cardiac tissue, use laser scanning of optical dyes to measure action potential propagation in the heart, Photo-release of caged compounds in cardiomyocytes and neurons, and apply TIRF imaging to resolve calcium signaling dynamics. His work has generated critical data on a wide variety of biological processes, ranging from EC-coupling, SA-nodal pacemaking mechanism, Regulation of ion channel proteins and Calcium signaling alternations in development and comparative biology. He has had a distinguished scientific career as a Professor of Physiology and Medicine at University of Pennsylvania, Georgetown University, and now as an Endowed professor at the three leading universities of SC. He has trained over 100 Graduate students, postdoctoral fellows, most of whom have leading academic positions in American, European, and Asian Universities. Among his many honors and services to the scientific community, in an advisory or editorial capacity, are also his services as the organizer of international high profile scientific conferences. He was awarded the German Government senior Scientist Alexander von Humboldt prize for his seminal work in cardiac electrophysiology.
Dr. Morad's current research is focused primarily on the complex protein interactions that regulate heart function that requires creation of transgenic animals that over-express or are deleted of proteins that are thought to be critical in pathophysiology of heart failure and cardiac arrhythmias. His Lab has pioneered the use of stem cell derived cardiomyocytes in probing the mechanisms underlying the CPVT1 arrhythmia using CRISPR/Cas9 gene editing technique. His gene editing approach may lead to new therapeutic approaches to treating life-threatening arrhythmias and to creation of tissue-based pacemaker using genetically engineered cells from patient dermal fibroblasts. His research for the past 50 years has been continuously funded by NIH.
He has maintained a lab at Mount Desert Biological Labs in Maine for 40 years, where he has cloned genes from marine species and has introduced them in mammalian hearts to prevent arrhythmias associated with cardiac failure.
- Ronald Evans Biography
- Salk Institute, USA
- Physiology and its transcriptional underpinning
- Lucio Ildebrando Cocco Biography
- University of Bologna, Italy
- Nuclear Signalling : Role of Inositol Lipids and Inositide Specific Phospholipase C
- Hee-Sup Shin Biography
- Center for Cognition and Sociality, IBS, Korea
- Neural mechanism of affective empathy
RONALD M. EVANS
The Salk Institute for Biological Studies
10010 North Torrey Pines Rd. / La Jolla, CA 92037
(858) 455-1316 / email@example.com
Present Position: Professor, The Salk Institute for Biological Studies
1966-1970 Bacteriology, B.A., Univ. of California, Los Angeles
1970-1974 Microbiology, Ph.D., Univ. of California, Los Angeles
1998-Present March of Dimes Chair in Molecular and Developmental Biology
1986-Present Professor, Gene Expression Laboratory, The Salk Institute
1985-2020 Investigator, Howard Hughes Medical Institute
1997-1998 Chairman of the Faculty, The Salk Institute for Biological Studies
1996-1999 Board of Trustees, The Salk Institute for Biological Studies
1990-1994 Board of Trustees, The Salk Institute for Biological Studies
1993-1994 Chairman of the Faculty, The Salk Institute for Biological Studies
1995-Present Adjunct Professor, Department of Neurosciences, Univ. of CA, San Diego
1989-Present Adjunct Professor, Department of Pharmacology, UCSD School of Medicine
1985-Present Adjunct Professor, Department of Biology, Univ. of California, San Diego
1984-1986 Sr. Member, Molecular Biology and Virology Laboratory,
The Salk Institute for Biological Studies
1983-1984 Associate Professor, Molecular Biology and Virology Laboratory
The Salk Institute for Biological Studies
1978-1983 Assistant Research Professor, Tumor Virology Laboratory
The Salk Institute for Biological Studies
1975-1978 Department of Molecular Cell Biology, The Rockefeller University
(Dr. James Darnell)
Honors and Awards
2022 G.H.A. Clowes Award for Outstanding Basic Cancer Research, AACR
2021 14th Asan Award in Medicine, Asan Foundation, Korea
2020 NOMIS Foundation Distinguished Scientist and Scholar award, Switzerland
2019 Charles H. Best International Award in Diabetes, University of Toronto
2018 Fellow, American Association for the Advancement of Science
2018 Louisa Gross Horwitz Prize, Columbia University
2017-2020 Co-Leader, Stand Up 2 Cancer American Assocation for Cancer Research
Catalyst Grant with support from Merck
2017 Bert and Natalie Vallee Award in BioMedical Science, Association for
Biochemistry and Molecular Biology
2016-2018 Co-Leader, Stand Up to Cancer/Cancer Research UK/Lustgarten DreamTeam
2016 Fellow, National Academy of Inventors
2015 Frontiers in Science Award, American Association of Clinical Endocrinologists
2014 Honorary Degree, University of Groningen, Netherlands
2014-2019 Distinguished Scholar Award, Lustgarten Foundation
2014 Fellow, American Association for Cancer Research
RONALD M. EVANS
2013 Distinguished Leader in Insulin Resistance Award, World Congress in Insulin
Resistance, Diabetes & Cardiovascular Disease
2013 Inaugural Lifetime Achievement Award, Samuel Waxman Cancer Research
2013 Dale Medal, Society for Endocrinology, UK
2012 Wolf Prize in Medicine, Wolf Foundation, Israel
2011 The Ellison Medical Foundation – Senior Scholar in Aging
2011 Rolf Sammet Guest Professorship Award, Goethe University, Frankfurt
2010 Heart Failure Association of America Award
2009 Ernst Knobil Award, UTHSCH
2009 Honorary Degree, Albany Medical College
2009 Honorary Degree, Mt. Sinai School of Medicine
2008 Endocrine Regulation Prize, IPSEN Foundation
2007 Albany Medical Center Prize in Medicine and Biomedical Research
2006 Harvey Prize, Technion University, Israel
2006 BIOCOM Life Sciences Heritage Award
2006 Gairdner Foundation International Award, Canada
2005 "Grande Medaille d'Or" of the French Academy of Sciences
2005 Glenn T. Seaborg Medal, UCLA
2004 Albert Lasker Basic Medical Research Award
2004 Simon M. Shubitz Cancer Prize and Lectureship, University of Chicago
2003 National Academy of Medicine
2003 Keio Medical Science Prize
2003 General Motors Cancer Research Foundation Alfred P. Sloan Medal
2003 March of Dimes Prize in Developmental Biology
2002 City of Medicine Award, Duke University
2000 1st Bristol-Myers Squibb Award for Distinguished Achieve. in Metab. Res.
1999 Fred Conrad Koch Award, The Endocrine Society
1997 Gerald Aurbach Memorial Award, Association for Bone & Mineral Res.
1997 American Academy of Arts and Sciences, Fellow
1996 Morton Lecture and Award, Biochemical Society, Univ. of Liverpool
1994 Dickson Prize in Medicine 1994-95, University of Pittsburgh
1994 California Scientist of the Year, 1994, California Museum of Science and
Industry and the California Museum Foundation
1994 Transatlantic Medal, Society for Endocrinology
1993 Edwin B. Astwood Lectureship Award, The Endocrine Society
1993 Fellow, The American Academy of Microbiology
1993 Robert J. and Claire Pasarow Foundation Award for Cancer Research
1992 Osborne and Mendel Award, American Institute of Nutrition
1991 Rita Levi Montalcini Award, Fidia Research Foundation Neuroscience
1991 Gregory Pincus Memorial Award, Worcester Found. for Experimental Bio.
1990 Eleventh C.P. Rhoads Memorial Award, American Assoc. for Cancer Res.
1989 Van Meter/Rorer Pharmaceuticals Prize, American Thyroid Association
1989 National Academy of Sciences, Member
1988 The Louis S. Goodman and Alfred Gilman Award by the American Society for
Pharmacology and Experimental Therapeutics
1988 Gregory Pincus Medal, Laurentian Society
1975-1978 National Institutes of Health, Fellowship
1975 Cancer Research Comm. of California, Research Associate Fellowship
RONALD M. EVANS
1974 University of California Alumni, Award for Academic Distinction
2022 Interconnection between the Gut, Brain and Microbiome for Metabolic Disease,
2020 Nuclear Receptors 2020 conference, Nassau, Bahamas
2019 PancWest conference, Stanford Cancer Institute/Stanford University
2018 National Academy of Inventors, Washington, D.C.
2018 Keystone Frontiers in Islet Biology, Keystone, CO
2017 Rady Children’s Hospital 8th Annual Pediatric Research Symp, San Diego
2017 Biennial Wylie W. Vale Memorial Lecture, Baylor College of Medicine, TX
2016 Wound Healing Society, San Diego
2016 Experimental Biology Meeting, San Diego
2015 CHOP Research Institute Annual Scientific Symposium, Philadelphia, PA
2014 EMBO Keynote Lecture, CNIC Conference, Madrid, Spain
2014 Sixth Biennial Great Lakes Nuclear Receptor Conference, Madison, WI
2013 11th Annual World Congress on Insulin Resistance, Diabetes & Cardiovascular
Disease, Los Angeles, CA
2013 XXI ISHR World Congress, International Society for Heart Res., San Diego
2012 UKC2012, US-Korea conference on Science, Technology and
Entrepreneurship, Los Angeles
2011 NCI Staff Scientist/Staff Clinician Retreat Keynote, Bethesda, MD
2011 Yale University Program in Integrative Cell Signaling and Neurobiology of
Metabolism Symposium, Yale University
2011 UCSD Chronobiology Symposium – From Cells to the Clinic, San Diego
2010 Aurbach Distinguished Lecture
2010 Distinguished Visiting Professor, Johns Hopkins
2010 9th International Congress on the Future of Breast Cancer, La Jolla, CA
2010 Inaugural Herbert Carter Lecture, University of Illinois
2009 Commencement Address, Albany Medical College
2009 Commencement Address, SUNY Buffalo School of Med., Biomedical Sciences
2009 New Frontiers in Skeletal Research: Bone, Fat and Brain Connect., ASBMR
2009 Symposium on Cancer Research, MD Anderson Cancer Center
2008 Inaugural Endocrine Research Showcase, Rutgers University
2007 Inaugural John Mendelsohn Visiting Professor in Cancer Medicine
2006 American Thyroid Association
2006 4th Annual COPP Lecture, University of British Columbia
2006 FASEB Summer Research Conference on Retinoids
2005 Frontiers of Clinical Investigation Symposium
2004 UCLA Department of Medicine, Div. of Endocrinology, Diabetes and
Hypertension, Diabetes Endocrinology Research Center (DERC) Gala
2004 3rd International Metabolic Diseases Drug Discovery World Summit
2004 Gordon Research Conference on Lipoprotein Metabolism
2002 2nd International Nuclear Receptor Meeting, Sumitomo Chemical Co. Ltd. and
Osaka Pharmaceuticals Co. Ltd.
2002 21st Symposium in Molecular Biology, The Pennsylvania State University
2002 FASEB Summer Research Conference on Mechanisms of Liver Growth,
Differentiation, and Molecular Pathogenesis of Hepatic Diseases
2002 XV Int’l. Ecdysone Workshop, Crete
RONALD M. EVANS
2001 Stowers Institute for Medical Research, Inaugural Symposium
2001 American Heart Association, North American Vascular Biology Organization
and the National Heart, Lung, and Blood Institute
1999 Keystone Symposia on Inflammatory Paradigms and the Vasculature
1998 Dorcas Cummings Memorial Lecture, CSHL Symposium on Transcription
1998 Keystone Symposia on Molecular and Cellular Biology of Gene Therapy
1991 Third Annual Usha Mahajani Symposium on Molecular Medicine
2019 Charles H. Best Lecture, University of Toronto, Canada
2019 Flexner Discovery Lecture, Vanderbilt University, TN
2019 President’s Research Seminar, Memorial Sloan Kettering Cancer Center, NY
2018 Edwin G. Krebs Lecture in Molecular Pharmacology at the University of
2018 The Malvin and Eleanor Mayer Lecture, Massachusetts Institute of
2017 Frank Brooks State of the Art Lecture (Basic Science), American Pancreatic
2017 Biennial Wylie W. Vale Memorial Lecture, Baylor College of Med., TX
2017 National Institute of Environmental Health Sciences Distinguished Lecture
2015 John Haddad Memorial Lecture, University of Pennsylvania
2015 Danny Thomas Lecture, St. Jude Children’s Research Hospital, Memphis, TN
2015 Richard M. Furlaud Distinguished Lecture, Rockefeller University
2014 Dr. Gerry Mueller Memorial Lecture, University of Wisconsin
2014 RG Williams Lecture, Genetics, University of Pennsylvania
2013 Chao Family Comprehensive Cancer Center Lecture, UC Irvine
2013 UCI-Inserm 2nd International Symposium: Epigenetic Control and Cellular
Plasticity, UC Irvine
2013 Barbara Deeb Memorial Lecture, University of Washington
2011 President’s Lecture, Endocrine Society Annual Meeting, Boston
2011 KROC Lecture, University of Massachusetts Medical Center
2010 Aurbach Distinguished Lecture, ASBMR
2010 4th Annual HFSA Basic Science Dist. Lecture, Heart Failure Soc. of America
2010 Scott Lecture, Northwestern University
2010 Sinsheimer Lecture, UC Santa Cruz
2010 Gladstone Distinguished Lecture, The Gladstone Inst. of Neurological Disease
2009 Ernst Knobil Distinguished Lecture, UTHSCH
2009 Public Lecture, Janelia Farms
2009 President’s Lecture, American College of Sports Medicine Annual Meeting
2009 Rudin-Kase Dean’s Lecture, Mt. Sinai School of Medicine
2009 Distinguished Scientist Seminar, Suny Buffalo SOM
2008 2008 Charlton Lecture, Tufts University School of Medicine
2008 Hyman J. Zimmerman Lecture in Hepatoxicity of the AASLD
2008 George Boxer Memorial Lecture, UMDNJ-Robert Wood Johnson Med School
2008 10th Annual Beckman Scholars Symposium, Distinguished Guest Speaker
2008 Steven Riven Lecture, Discovery Lecture Series, Vanderbilt University
2007 Honors Program Lecture, New York University
2007 AACR Frontiers in Cancer Prevention Distinguished Lecture
2007 Sackler Distinguished Lecture, Royal College of Physicians, Cambridge, UK
RONALD M. EVANS
2007 Marcel-Piché Lecture, Institut de recherches cliniques de Montréal (IRCM)
2007 Fritz Lipmann Lectureship, American Soc. for Biochem. and Mol. Bio.
2006 UC Berkeley Lepkovsky Memorial Lecture
2006 The Samuel Rudin Distinguished Visiting Professorship Lecture
2006 50th Havel Lecture
2005 Fred Kern Lecturer, Kern Aspen Lipid Conference
2005 School of Pharmacy Distinguished Lecture, University of Pittsburgh
2005 Senior Vice Chancellor Laureate Lecture, University of Pittsburgh
2005 Alexander and Helena Schonfeld Lecture, Washington University
2004 Jane Darnell Memorial Lecture, The Rockefeller University
2003 Inaugural Presidential Lecture, Dartmouth College
2002 The 214th Lilly Lecture, Eli Lilly and Company
2002 Ray A. and Robert L. Kroc Lecturer, Joslin Diabetes Center
2002 Endocrine Lectureship, Yale University
2002 President’s Research Lecture, Memorial Sloan-Kettering
2001 Carmella Louise Riker Lecture, Oregon Health Sciences University
2001 Dean’s Lecture, University of Texas-Houston
2000 Lya and Harrison Latta Lecture, University of California, Los Angeles
1998 Burroughs Wellcome Visiting Professor, University of Massachusetts
1998 Dorcas Cummings Memorial Lecture, Cold Spring Harbor Symp. on
1997 Joseph C. Calandra Lecture, Northwestern University
1997 Ada C. Doisy Lecture in Biochemistry, Univ. of Ill.Champaign-Urbana
1997 Carl F. Schmidt Honorary Lecture, Univ. of Pennsylvania Sch. of Med.
1996 First Alvin Taurog Lectureship in Pharmacology, Southwestern Med. Ctr.
1996 Woodward Visiting Professor, Memorial Sloan-Kettering
1996 Glaxo-Wellcome/Duke University Lecture in Biomedical Sciences
1995 S. Richardson Hill, Jr. Visiting Professor, Univ. of Alabama
1995 Harvey Society Lecture, Rockefeller University
1995 Matrone Lecture, North Carolina State University
1991 Mortimer B. Lipsett Memorial Lecture, National Institutes of Health
1991 Sixth Annual Pfizer Lecture in Honor of Konrad Bloch, Harvard Univ.
1991 McGinnis Memorial Lecture, Duke University
1988 Sandoz Lecturer, Canadian Society of Endocrinology and Metabolism
1987 Leslie L. Bennett Lecture, University of California, San Francisco
2022 Cell Metabolism, Advisory Board Member
2022 Cell, Advisory Board Member
2014-2017 Nuclear Receptor Signaling, Co-Editor-in-Chief (with O’Malley, McKenna)
2012-2016 Current Opinions in Genetics & Development, Section Editor
2009-2015 Science Signaling
2008-present Cancer Prevention Research, Deputy Editor
2004-2022 Cell Metabolism, Editorial Board
1999-2022 Cell, Editorial Board
1996-present Proceedings of the National Academy of Sciences, Editorial Board
1996-2012 Hormones and Signaling, Academic Press Series, Editorial Board
1993-1997 Molecular Endocrinology, Editor
RONALD M. EVANS
1993 Current Opinion in Cell Biology, Co-Editor
1992-present Genes and Development, Editorial Board
1992-1993 Receptors and Channels, Editorial Board
1991-1995 Annual Review of Biochemistry, Editorial Committee
1991-1993 Protein Science, Editorial Advisory Board
1987-1993 Neuron, Associate Editor
1985-1993 Molecular Brain Research, Associate Editor
1985-1990 Journal of Neuroscience, Associate Editor
Committees and Boards:
Ongoing Salk Institute Awards Committee, Appointments Committee, Senior Faculty
Recruitment Committee, External Relations
Ongoing Salk Institute Board of Trustees committees: Intellectual Property/Technology
Transfer, Development and Communications
Ongoing Program Leader, Salk Cancer Center
2021-present Member, Windows Therapetics Scientific Advisory Board
2021-present Member, NURRX Scientific Advisory Board
2021-present Member Emeritus, Lustgarten Foundation Scientific Advisory Board
2017-present March of Dimes and Richard B. Johnston, Jr., Prize in Developmental Biology
2020 King Faisal Prize in Science Committee, Saudi Arabia
2016-2018 AACR Laboratory Research Award Committee
2016-present Let’s Win! Scientific Advisory Board
2015-2017 AACR Nominating Committee
2015-present AACR Innovative Research Grant Committee
2015-present AACR Program Committee
2014-2021 The Lustgarten Foundation Scientific Advisory Board
2014-2017 AACR Board of Directors
2013-present Lurie Prize Selection Committee
2013-2015 Life Sciences Institute Scientific Advisory Board
2012-2015 eLife Publications Committee
2010-2012 AACR Nominating Committee
2009-present AACR Council of Scientific Advisors
2007-2012 Board of Governors Foundation for Biomedical Research
2007-present Ad Hoc National Academy of Sciences Search and Screening Committee
2007-present Ad Hoc National Academy of Sciences Class Membership Committee
2007-present AACR Ad Hoc Grants Advisory Committee
2007-2014 Children’s Hospital Boston Scientific Advisory Committee
2006-2017 LuMind (formerly DSRTF) Scientific Advisory Board
2006-2012 Pasarow Foundation Board of Directors
2006-present AACR Council of Scientific Advisors
2005 Chair, Kirk A Landon-AACR Prize Selection Committee for Basic Cancer
2005 NIH, Molecular and Cellular Endocrinology Study Section
2004 Fondazione Giovanni Lorenzini Medical Science Found. Int'l. Advisory Board
2002 2003 AACR-NFCR Professorship in Basic Cancer Research Committee
2002 Chairperson, AACR Program Committee
2001 Kirk A. Landon-AACR Prize for Basic Cancer Research Committee
2001 Chair, AACR-Pezcoller International Award for Cancer Research Committee
RONALD M. EVANS
1999-2005 Osaka Bioscience Institute, Scientific Advisory Board
1996-2012 Dana Farber Cancer Institute Scientific Advisory Board
1996-2014 Massachusetts General Hospital, External Scientific Advisory Board
1991 General Motors Cancer Research Foundation
Alfred P. Sloan Jr. Selection Committee
1990-1999 Salk Institute for Biological Studies, Board of Trustees
1989-1991 Searle Scholars Program Committee
1987-2000 Pew Scholars Program in the Biomedical Sciences
National Advisory Committee
1987 City of Hope, External Scientific Advisory Board
1987-1990 American Cancer Society, Fellowship Screening Committee
1984-1985 Molecular Neurobiology Study Section, NIH
1981-1986 Molecular Biology Study Section (NIH)
Biotech/Pharma Scientific Advisory Boards:
2020–present Adlai Nortye USA Inc., Chair, Scientific Advisory Board
2019-present Diagon, Inc. Founder and Scientic Advisory Board
2016-present Amgen, Scientific Advisory Board
2015-present Metacrine, Founder and Scientific Advisory Board
2013-present Mitobridge, Founder and Scientific Advisory Board
2013-2014 Seragon, Scientific Advisory Board
2009-2013 Aragon, Scientific Advisory Board
2008-2017 ReSet, Founder and Scientific Advisory Board
2008-2012 Epizyme, Scientific Advisory Board
2005-present Syndax Pharmaceuticals, Founder and Chair Scientific Advisory Board
2005-2012 Exelixis, Inc., Scientific Advisory Board
2005-2012 Brain Cells Inc., Scientific Advisory Board
2003 Genomics Institute of Novartis Research Found., Scientific Advisory Board
2001 X-Ceptor Therapeutics Inc., Founder and Chair, Scientific Advisory Board
1988-2012 Ligand Pharmaceuticals, Founder and Chair, Scientific Advisory Board
1983-1995 SIBIA, Scientific Advisory Board
2019 Co-Chair, Ipsen-Science Symposium on Biological Complexity
2018 Co-Chair, AACR Pancreatic Conference
2016 Co-Chair, AACR Annual Meeting
2014 Co-Organizer, Cold Spring Harbor Lab., Nuclear Receptors and Disease
2012 Co-Organizer, Cold Spring Harbor Lab., Nuclear Receptors and Disease
2012 Co-Organizer, Keystone Symposium, “Nuclear Receptor Matrix: Reloaded”
2012 Co-Organizer, Salk Institute/Nature/Fondation IPSEN, Symposium on
Biological Complexity: Immunity and Inflammation
2011 Co-Organizer, Cambridge Res. Inst. “Unanswered Questions in Transcription”
2011 Co-Organizer, Salk Institute/Nature/Fondation IPSEN, Symposium on
2010 Co-Organizer, Cold Spring Harbor Lab., Nuclear Receptors and Disease
2010 Co-Organizer, Salk Institute/Nature/Fondation IPSEN, Symposium on
2009 Co-Chairperson, AACR Special Conference, “Metabolism and Cancer”
RONALD M. EVANS
2009 Co-Organizer, Salk Institute/Nature/Fondation IPSEN, Symposium on
2008 Co-Organizer, Cold Spring Harbor Lab., Nuclear Receptors: Bench to Bedside
2008 Co-Organizer, Salk Institute/Nature/Fondation IPSEN, Symposium on
2007 Co-Organizer, Salk Institute/Nature/Fondation IPSEN, Symposium on
Biological Complexity: Diseases of Transcription
2006 Co-Organizer, Cold Spring Harbor Lab., Nuclear Receptors: Bench to Bedside
2005 Co-Organizer, Keystone Symposium on Bioactive Lipids, Lipidomics and their
2003 Co-Organizer, Hot Topics in Endocrinology 2003 "The Role of Nuclear
Receptors in Cardiovascular Disease"
2003 Co-Organizer, Keystone Symposium on PPARs: Transcriptional Regulators of
Metabolism and Metabolic Disease
2002 Co-Organizer, UCSD/Salk/Nature Medicine, Days of Molecular Medicine
2001 Co-Organizer, Keystone Symposium on The PPARs: A Transcription Odyssey
2000 Co-Organizer, Keystone Symposium on Nuclear Receptors
1999 Co-Organizer, Keystone Symposium on The PPARs: Transcriptional
Mechanisms and Role in Human Disease
1998 Co-Chair, Keystone Symposium on Nuclear Receptor Gene Family,
Lake Tahoe, CA
1996 Co-Chair, Mahajani Symposium, Univ. of California, San Diego
1996 Co-Organizer, Keystone Symposium on Steroid/Thyroid/Retinoic Acid
Gene Family, Lake Tahoe, CA
1995 Co-Chair, Mahajani Symposium, Univ. of California, San Diego
1995 Co-Chair, AACR Special Conf. Mechanism of Action of Retinoids,
Vitamin D, and Steroid Hormones, Whistler, B.C., Canada
1994 Co-Chair, Mahajani Symposium, Univ. of California, San Diego
1993 Co-Chair, AACR Special Conf. in Cancer Research, Banff, Canada
1992 Chair, Gordon Research Conference on Hormone Action
1990 Chair, Gordon Research Conference on Molecular Genetics
1988 Vice-Chair, Gordon Research Conference on Molecular Genetics
1987 Co-chair, AACR Conference on Steroid Hormone Action
Approximately 5 per month
2020 AACR-MPM Transformative Cancer Research Grants Scientific Review
2020 Salk Cancer Center Pilot Grants
2020 Samuel Waxman Cancer Research Foundation/The Alan B. Slifka
Foundation/Israel Cancer Research Fund research grants
2018 EMBO Long-Term Fellowship review committee
2017 SU2C‐Lustgarten Foundation Joint Scientific Advisory Committee
2017 National Review Foundation of Korea
2016 Chan Zuckerberg Biohub Investigatorships
2016 AACR Innovative Research Grants
2014, 15 AACR Nominating Committee
RONALD M. EVANS
Ad hoc NIDDK Study Section
Ad hoc Tumor Boards (Cedars Sinai)
American Association of Cancer Research
Society for Developmental Biology
Society for Neuroscience
2019 American Association for the Advancement of Science, Fellow
2016 National Academy of Inventors, Fellow
2014 American Association for Cancer Research, Fellow
2007 American Philosophical Society
2006 European Molecular Biology Organization (EMBO), Associate Member
2003 Institute of Medicine of the National Academies
1997 American Academy of Arts and Sciences, Fellow
1995 The Harvey Society
1993 American Society for Microbiology, Fellow
1989 National Academy of Science, Member
315 issued (295 licensed)
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RONALD M. EVANS
5. Evans RM, Fraser N, Ziff E, Weber J, Wilson M, Darnell JE. The initiation sites for
RNA transcription in Ad2 DNA. Cell. 1977 Nov;12(3):733-9. PubMed PMID: 922890.
6. Jelinek W, Evans R, Wilson M, Salditt-Georgieff M, Darnell JE. Oligonucleotides in
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processing of a nuclear RNA precursor to rat pregrowth hormone messenger RNA. Nucleic
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11. Soreq H, Harpold M, Evans R, Darnell JE Jr, Bancroft FC. Rat growth hormone gene:
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12. Harpold MM, Evans RM, Salditt-Georgieff M, Darnell JE. Production of mRNA in
Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration
of nine specific mRNA sequences. Cell. 1979 Aug;17(4):1025-35. PubMed PMID: 487428.
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calcitonin gene associated with RNA polymorphism. Nature. 1981 Mar 5;290(5801):63-5.
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15. Potter E, Nicolaisen AK, Ong ES, Evans RM, Rosenfeld MG. Thyrotropin-releasing
hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA
transcript. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6662-6. PubMed PMID: 6796963;
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RONALD M. EVANS
16. Amara SG, Jonas V, O'Neil JA, Vale W, Rivier J, Roos BA, Evans RM, Rosenfeld
MG. Calcitonin COOH-terminal cleavage peptide as a model for identification of novel
neuropeptides predicted by recombinant DNA analysis. J Biol Chem. 1982 Mar
10;257(5):2129-32. PubMed PMID: 6895892. [RESEARCH ARTICLE]
17. Rosenfeld MG, Lin CR, Amara SG, Stolarsky L, Roos BA, Ong ES, Evans RM.
Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing
events. Proc Natl Acad Sci U S A. 1982 Mar;79(6):1717-21. PubMed PMID: 6952224;
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18. Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM. Alternative RNA processing
in calcitonin gene expression generates mRNAs encoding different polypeptide products.
Nature. 1982 Jul 15;298(5871):240-4. PubMed PMID: 6283379. [RESEARCH ARTICLE]
19. Doehmer J, Barinaga M, Vale W, Rosenfeld MG, Verma IM, Evans RM. Introduction
of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression
and regulation. Proc Natl Acad Sci U S A. 1982 Apr;79(7):2268-72. PubMed PMID: 6285377;
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20. Murdoch GH, Potter E, Nicolaisen AK, Evans RM, Rosenfeld MG. Epidermal growth
factor rapidly stimulates prolactin gene transcription. Nature. 1982 Nov 11;300(5888):192-4.
PubMed PMID: 6982423. [RESEARCH ARTICLE]
21. Evans RM, Birnberg NC, Rosenfeld MG. Glucocorticoid and thyroid hormones
transcriptionally regulate growth hormone gene expression. Proc Natl Acad Sci U S A. 1982
Dec;79(24):7659-63. PubMed PMID: 6296844; PubMed Central PMCID: PMC347407.
22. Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC,
Evans RM. Dramatic growth of mice that develop from eggs microinjected with
metallothionein-growth hormone fusion genes. Nature. 1982 Dec 16;300(5893):611-5.
PubMed PMID: 6958982; PubMed Central PMCID: PMC4881848 [RESEARCH ARTICLE]
23. Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale
WW, Evans RM. Production of a novel neuropeptide encoded by the calcitonin gene via
tissue-specific RNA processing. Nature. 1983 Jul 14-20;304(5922):129-35. PubMed PMID:
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24. Fisher LA, Kikkawa DO, Rivier JE, Amara SG, Evans RM, Rosenfeld MG, Vale WW,
Brown MR. Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related
peptide. Nature. 1983 Oct 6-12;305(5934):534-6. PubMed PMID: 6604878. [RESEARCH
25. Barinaga M, Yamonoto G, Rivier C, Vale W, Evans R, Rosenfeld MG. Transcriptional
regulation of growth hormone gene expression by growth hormone-releasing factor. Nature.
1983 Nov 3-9;306(5938):84-5. PubMed PMID: 6415487 [RESEARCH ARTICLE]
RONALD M. EVANS
26. Mayo KE, Vale W, Rivier J, Rosenfeld MG, Evans RM. Expression-cloning and
sequence of a cDNA encoding human growth hormone-releasing factor. Nature. 1983 Nov 3-
9;306(5938):86-8. PubMed PMID: 6415488. [RESEARCH ARTICLE]
27. Murdoch GH, Franco R, Evans RM, Rosenfeld MG. Polypeptide hormone regulation
of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of
the prolactin gene and the phosphorylation of a specific nuclear protein. J Biol Chem. 1983
Dec 25;258(24):15329-35. PubMed PMID: 6418746. [RESEARCH ARTICLE]
28. Amara SG, Evans RM, Rosenfeld MG. Calcitonin/calcitonin gene-related peptide
transcription unit: tissue-specific expression involves selective use of alternative
polyadenylation sites. Mol Cell Biol. 1984 Oct;4(10):2151-60. PubMed PMID: 6334229;
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29. Lin CR, Chen WS, Kruiger W, Stolarsky LS, Weber W, Evans RM, Verma IM, Gill GN,
Rosenfeld MG. Expression cloning of human EGF receptor complementary DNA: gene
amplification and three related messenger RNA products in A431 cells. Science. 1984 May
25;224(4651):843-8. PubMed PMID: 6326261. [RESEARCH ARTICLE]
30. Miller AD, Ong ES, Rosenfeld MG, Verma IM, Evans RM. Infectious and selectable
retrovirus containing an inducible rat growth hormone minigene. Science. 1984 Sep
7;225(4666):993-8. PubMed PMID: 6089340. [RESEARCH ARTICLE]
31. Supowit SC, Potter E, Evans RM, Rosenfeld MG. Polypeptide hormone regulation of
gene transcription: specific 5' genomic sequences are required for epidermal growth factor
and phorbol ester regulation of prolactin gene expression. Proc Natl Acad Sci U S A. 1984
May;81(10):2975-9. PubMed PMID: 6328483; PubMed Central PMCID: PMC345203
32. Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM. Independent effects
of growth hormone releasing factor on growth hormone release and gene transcription.
Nature. 1985 Mar 21-27;314(6008):279-81. PubMed PMID: 2858817 [RESEARCH
33. Mayo KE, Cerelli GM, Lebo RV, Bruce BD, Rosenfeld MG, Evans RM. Gene
encoding human growth hormone-releasing factor precursor: structure, sequence, and
chromosomal assignment. Proc Natl Acad Sci U S A. 1985 Jan;82(1):63-7. PubMed PMID:
3918305; PubMed Central PMCID: PMC396971. [RESEARCH ARTICLE]
34. Jonas V, Lin CR, Kawashima E, Semon D, Swanson LW, Mermod JJ, Evans RM,
Rosenfeld MG. Alternative RNA processing events in human calcitonin/calcitonin generelated peptide gene expression. Proc Natl Acad Sci U S A. 1985 Apr;82(7):1994-8. PubMed
PMID: 3872459; PubMed Central PMCID: PMC397471 [RESEARCH ARTICLE]
35. Mayo KE, Cerelli GM, Rosenfeld MG, Evans RM. Characterization of cDNA and
genomic clones encoding the precursor to rat hypothalamic growth hormone-releasing factor.
Nature. 1985 Apr 4-10;314(6010):464-7. PubMed PMID: 3920534. [RESEARCH ARTICLE]
RONALD M. EVANS
36. Murdoch GH, Waterman M, Evans RM, Rosenfeld MG. Molecular mechanisms of
phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene
transcription. J Biol Chem. 1985 Sep 25;260(21):11852-8. PubMed PMID: 3930485
37. Waterman M, Murdoch GH, Evans RM, Rosenfeld MG. Cyclic AMP regulation of
eukaryotic gene transcription by two discrete molecular mechanisms. Science. 1985 Jul
19;229(4710):267-9. PubMed PMID: 2990047. [RESEARCH ARTICLE]
38. Gill GN, Weber W, Thompson DM, Lin C, Evans RM, Rosenfeld MG, Gamou S,
Shimizu N. Relationship between production of epidermal growth factor receptors, gene
amplification, and chromosome 7 translocation in variant A431 cells. Somat Cell Mol Genet.
1985 Jul;11(4):309-18. PubMed PMID: 2410984. [RESEARCH ARTICLE]
39. Hammer RE, Brinster RL, Rosenfeld MG, Evans RM, Mayo KE. Expression of human
growth hormone-releasing factor in transgenic mice results in increased somatic growth.
Nature. 1985 May 30-Jun 5;315(6018):413-6. PubMed PMID: 3923368. [RESEARCH
40. Weinberger C, Hollenberg SM, Ong ES, Harmon JM, Brower ST, Cidlowski J,
Thompson EB, Rosenfeld MG, Evans RM. Identification of human glucocorticoid receptor
complementary DNA clones by epitope selection. Science. 1985 May 10;228(4700):740-2.
PubMed PMID: 2581314. [RESEARCH ARTICLE]
41. Swanson LW, Simmons DM, Arriza J, Hammer R, Brinster R, Rosenfeld MG, Evans
RM. Novel developmental specificity in the nervous system of transgenic animals expressing
growth hormone fusion genes. Nature. 1985 Sep 26-Oct 2;317(6035):363-6. PubMed PMID:
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42. Amara SG, Arriza JL, Leff SE, Swanson LW, Evans RM, Rosenfeld MG. Expression
in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin generelated peptide. Science. 1985 Sep 13;229(4718):1094-7. PubMed PMID: 2994212
43. Sabate MI, Stolarsky LS, Polak JM, Bloom SR, Varndell IM, Ghatei MA, Evans RM,
Rosenfeld MG. Regulation of neuroendocrine gene expression by alternative RNA
processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells.
J Biol Chem. 1985 Mar 10;260(5):2589-92. PubMed PMID: 2982827 [RESEARCH
44. van der Putten H, Botteri FM, Miller AD, Rosenfeld MG, Fan H, Evans RM, Verma IM.
Efficient insertion of genes into the mouse germ line via retroviral vectors. Proc Natl Acad Sci
U S A. 1985 Sep;82(18):6148-52. PubMed PMID: 3862122; PubMed Central PMCID:
PMC391009. [RESEARCH ARTICLE]
45. Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB,
Rosenfeld MG, Evans RM. Primary structure and expression of a functional human
glucocorticoid receptor cDNA. Nature. 1985 Dec 19-1986 Jan 1;318(6047):635-41. PubMed
PMID: 2867473 NIHMSID 989142 [RESEARCH ARTICLE]
RONALD M. EVANS
46. Weinberger C, Hollenberg SM, Rosenfeld MG, Evans RM. Domain structure of
human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. Nature.
1985 Dec 19-1986 Jan 1;318(6047):670-2. PubMed PMID: 3841189. [RESEARCH
47. Lin CR, Chen WS, Lazar CS, Carpenter CD, Gill GN, Evans RM, Rosenfeld MG.
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF
binding regulate functional receptor loss by independent mechanisms. Cell. 1986 Mar
28;44(6):839-48. PubMed PMID: 3006920. [RESEARCH ARTICLE]
48. Nelson C, Crenshaw EB 3rd, Franco R, Lira SA, Albert VR, Evans RM, Rosenfeld
MG. Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression
of rat prolactin and growth hormone genes. Nature. 1986 Aug 7-13;322(6079):557-62.
PubMed PMID: 3736673. [RESEARCH ARTICLE]
49. Mayo KE, Cerelli GM, Spiess J, Rivier J, Rosenfeld MG, Evans RM, Vale W. Inhibin
A-subunit cDNAs from porcine ovary and human placenta. Proc Natl Acad Sci U S A. 1986
Aug;83(16):5849-53. PubMed PMID: 3016724; PubMed Central PMCID: PMC386393
50. Giguère V, Hollenberg SM, Rosenfeld MG, Evans RM. Functional domains of the
human glucocorticoid receptor. Cell. 1986 Aug 29;46(5):645-52. PubMed PMID: 3742595.
51. Weinberger C, Thompson CC, Ong ES, Lebo R, Gruol DJ, Evans RM. The c-erb-A
gene encodes a thyroid hormone receptor. Nature. 1986 Dec 18-31;324(6098):641-6.
PubMed PMID: 2879243 [RESEARCH ARTICLE]
52. Elsholtz HP, Mangalam HJ, Potter E, Albert VR, Supowit S, Evans RM, Rosenfeld
MG. Two different cis-active elements transfer the transcriptional effects of both EGF and
phorbol esters. Science. 1986 Dec 19;234(4783):1552-7. PubMed PMID: 3491428
53. Leff SE, Evans RM, Rosenfeld MG. Splice commitment dictates neuron-specific
alternative RNA processing in calcitonin/CGRP gene expression. Cell. 1987 Feb
13;48(3):517-24. PubMed PMID: 2879637. [RESEARCH ARTICLE]
54. Hollenberg SM, Giguere V, Segui P, Evans RM. Colocalization of DNA-binding and
transcriptional activation functions in the human glucocorticoid receptor. Cell. 1987 Apr
10;49(1):39-46. PubMed PMID: 3829127. [RESEARCH ARTICLE]
55. Botteri FM, van der Putten H, Wong DF, Sauvage CA, Evans RM. Unexpected thymic
hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40
large T antigen. Mol Cell Biol. 1987 Sep;7(9):3178-84. Erratum in: Mol Cell Biol 1987
Dec;7(12):4603. PubMed PMID: 3118193; PubMed Central PMCID: PMC367952.
RONALD M. EVANS
56. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans
RM. Cloning of human mineralocorticoid receptor complementary DNA: structural and
functional kinship with the glucocorticoid receptor. Science. 1987 Sep 25;237(4822):1610-4.
PubMed PMID: 3629259 [RESEARCH ARTICLE]
57. Thompson CC, Weinberger C, Lebo R, Evans RM. Identification of a novel thyroid
hormone receptor expressed in the mammalian central nervous system. Science. 1987 Sep
25;237(4822):1610-4. PubMed PMID: 3629259 [RESEARCH ARTICLE]
58. Giguere V, Ong ES, Segui P, Evans RM. Identification of a receptor for the
morphogen retinoic acid. Nature. 1987 Dec 17-23;330(6149):624-9. PubMed PMID:
2825036. [RESEARCH ARTICLE]
59. Glass CK, Franco R, Weinberger C, Albert VR, Evans RM, Rosenfeld MG. A c-erb-A
binding site in rat growth hormone gene mediates trans-activation by thyroid hormone.
Nature. 1987 Oct 22-28;329(6141):738-41. PubMed PMID: 3313046. [RESEARCH
60. Meunier H, Rivier C, Evans RM, Vale W. Gonadal and extragonadal expression of
inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Proc
Natl Acad Sci U S A. 1988 Jan;85(1):247-51. PubMed PMID: 2829170; PubMed Central
PMCID: PMC279521. [RESEARCH ARTICLE]
61. Giguère V, Yang N, Segui P, Evans RM. Identification of a new class of steroid
hormone receptors. Nature. 1988 Jan 7;331(6151):91-4. PubMed PMID: 3267207.
62. Pratt WB, Jolly DJ, Pratt DV, Hollenberg SM, Giguere V, Cadepond FM, SchweizerGroyer G, Catelli MG, Evans RM, Baulieu EE. A region in the steroid binding domain
determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex. J Biol
Chem. 1988 Jan 5;263(1):267-73. PubMed PMID: 3335498. [RESEARCH ARTICLE]
63. Waterman ML, Adler S, Nelson C, Greene GL, Evans RM, Rosenfeld MG. A single
domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional
activation of the rat prolactin gene. Mol Endocrinol. 1988 Jan;2(1):14-21. PubMed PMID:
3398840 [RESEARCH ARTICLE]
64. Mayo KE, Hammer RE, Swanson LW, Brinster RL, Rosenfeld MG, Evans RM.
Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormonereleasing factor gene. Mol Endocrinol. 1988 Jul;2(7):606-12. PubMed PMID: 3137455
65. Borrelli E, Heyman R, Hsi M, Evans RM. Targeting of an inducible toxic phenotype in
animal cells. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7572-6. PubMed PMID: 2845412;
PubMed Central PMCID: PMC282234. [RESEARCH ARTICLE]
66. Drabkin H, Kao FT, Hartz J, Hart I, Gazdar A, Weinberger C, Evans R, Gerber M.
Localization of human ERBA2 to the 3p22----3p24.1 region of chromosome 3 and variable
RONALD M. EVANS
deletion in small cell lung cancer. Proc Natl Acad Sci U S A. 1988 Dec;85(23):9258-62.
PubMed PMID: 2848257; PubMed Central PMCID: PMC282718 [RESEARCH ARTICLE]
67. Umesono K, Giguere V, Glass CK, Rosenfeld MG, Evans RM. Retinoic acid and
thyroid hormone induce gene expression through a common responsive element. Nature.
1988 Nov 17;336(6196):262-5. PubMed PMID: 2848197 [RESEARCH ARTICLE]
68. Arriza JL, Simerly RB, Swanson LW, Evans RM. The neuronal mineralocorticoid
receptor as a mediator of glucocorticoid response. Neuron. 1988 Nov;1(9):887-900. PubMed
PMID: 2856104. [RESEARCH ARTICLE]
69. Oro AE, Ong ES, Margolis JS, Posakony JW, McKeown M, Evans RM. The
Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Nature.
1988 Dec 1;336(6198):493-6. PubMed PMID: 2848202. [RESEARCH ARTICLE]
70. Oro AE, Hollenberg SM, Evans RM. Transcriptional inhibition by a glucocorticoid
receptor-beta-galactosidase fusion protein. Cell. 1988 Dec 23;55(6):1109-14. PubMed PMID:
3144438 [RESEARCH ARTICLE]
71. Hollenberg SM, Evans RM. Multiple and cooperative trans-activation domains of the
human glucocorticoid receptor. Cell. 1988 Dec 2;55(5):899-906. PubMed PMID: 3191531.
72. Evans RM. The steroid and thyroid hormone receptor superfamily. Science. 1988 May
13;240(4854):889-95. Review. PubMed PMID: 3283939 PubMed Central PMCID:
PMC6159881 [RESEARCH ARTICLE]
73. Evans RM, Hollenberg SM. Zinc fingers: gilt by association. Cell. 1988 Jan
15;52(1):1-3. Review. Erratum in: Cell 1988 Mar 11;52(5):783. PubMed PMID: 3125980
74. Giguère V, Ong ES, Evans RM, Tabin CJ. Spatial and temporal expression of the
retinoic acid receptor in the regenerating amphibian limb. Nature. 1989 Feb 9;337(6207):566-
9. Erratum in: Nature 1989 Sep 7;341(6237):80. PubMed PMID: 2536901. [RESEARCH
75. Evans RM, Arriza JL. A molecular framework for the actions of glucocorticoid
hormones in the nervous system. Neuron. 1989 Feb;2(2):1105-12. Review. PubMed PMID:
2696502 [RESEARCH ARTICLE]
76. Heyman RA, Borrelli E, Lesley J, Anderson D, Richman DD, Baird SM, Hyman R,
Evans RM. Thymidine kinase obliteration: creation of transgenic mice with controlled immune
deficiency. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2698-702. PubMed PMID: 2539597;
PubMed Central PMCID: PMC286985 [RESEARCH ARTICLE]
77. Thompson CC, Evans RM. Trans-activation by thyroid hormone receptors: functional
parallels with steroid hormone receptors. Proc Natl Acad Sci U S A. 1989 May;86(10):3494-8.
PubMed PMID: 2726731; PubMed Central PMCID: PMC287164 [RESEARCH ARTICLE]
RONALD M. EVANS
78. Borrelli E, Heyman RA, Arias C, Sawchenko PE, Evans RM. Transgenic mice with
inducible dwarfism. Nature. 1989 Jun 15;339(6225):538-41. PubMed PMID: 2733785.
79. Damm K, Thompson CC, Evans RM. Protein encoded by v-erbA functions as a
thyroid-hormone receptor antagonist. Nature. 1989 Jun 22;339(6226):593-7. PubMed PMID:
2733791 [RESEARCH ARTICLE]
80. Umesono K, Evans RM. Determinants of target gene specificity for steroid/thyroid
hormone receptors. Cell. 1989 Jun 30;57(7):1139-46. PubMed PMID: 2500251.
81. Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y,
Imawari M, Evans RM, Takaku F. A functional retinoic acid receptor encoded by the gene on
human chromosome 12. Mol Endocrinol. 1990 Jun;4(6):837-44. PubMed PMID: 2172793.
82. Sucov HM, Murakami KK, Evans RM. Characterization of an autoregulated response
element in the mouse retinoic acid receptor type beta gene. Proc Natl Acad Sci U S A. 1990
Jul;87(14):5392-6. PubMed PMID: 2164682; PubMed Central PMCID: PMC54330.
83. Schüle R, Umesono K, Mangelsdorf DJ, Bolado J, Pike JW, Evans RM. Jun-Fos and
receptors for vitamins A and D recognize a common response element in the human
osteocalcin gene. Cell. 1990 May 4;61(3):497-504. PubMed PMID: 2159384. [RESEARCH
84. Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM. Nuclear receptor that identifies a
novel retinoic acid response pathway. Nature. 1990 May 17;345(6272):224-9. PubMed PMID:
2159111. [RESEARCH ARTICLE]
85. Oro AE, McKeown M, Evans RM. Relationship between the product of the Drosophila
ultraspiracle locus and the vertebrate retinoid X receptor. Nature. 1990 Sep
20;347(6290):298-301. PubMed PMID: 2169594. [RESEARCH ARTICLE]
86. Moolten FL, Wells JM, Heyman RA, Evans RM. Lymphoma regression induced by
ganciclovir in mice bearing a herpes thymidine kinase transgene. Hum Gene Ther. 1990
Summer;1(2):125-34. PubMed PMID: 1964092 [RESEARCH ARTICLE]
87. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, Evans
RM. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell.
1990 Sep 21;62(6):1217-26. PubMed PMID: 2169353 [RESEARCH ARTICLE]
88. Yang N, Schüle R, Mangelsdorf DJ, Evans RM. Characterization of DNA binding and
retinoic acid binding properties of retinoic acid receptor. Proc Natl Acad Sci U S A. 1991 May
1;88(9):3559-63. PubMed PMID: 1850832; PubMed Central PMCID: PMC51491
RONALD M. EVANS
89. Umesono K, Murakami KK, Thompson CC, Evans RM. Direct repeats as selective
response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell.
1991 Jun 28;65(7):1255-66. PubMed PMID: 1648450 PubMed Central PMCID: PMC6159884
90. Schüle R, Rangarajan P, Yang N, Kliewer S, Ransone LJ, Bolado J, Verma IM, Evans
RM. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci U S
A. 1991 Jul 15;88(14):6092-6. PubMed PMID: 1648728; PubMed Central PMCID:
PMC52028. [RESEARCH ARTICLE]
91. Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV,
Dmitrovsky E, Evans RM. Chromosomal translocation t(15;17) in human acute promyelocytic
leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug
23;66(4):663-74. PubMed PMID: 1652368 [RESEARCH ARTICLE]
92. Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM. A direct
repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR
and RAR. Cell. 1991 Aug 9;66(3):555-61. PubMed PMID: 1651173. [RESEARCH ARTICLE]
93. Cadepond F, Schweizer-Groyer G, Segard-Maurel I, Jibard N, Hollenberg SM,
Giguère V, Evans RM, Baulieu EE. Heat shock protein 90 as a critical factor in maintaining
glucocorticosteroid receptor in a nonfunctional state. J Biol Chem. 1991 Mar 25;266(9):5834-
41. PubMed PMID: 2005120 [RESEARCH ARTICLE]
94. Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM. Retinoid
X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc Natl Acad Sci U S A.
1992 Feb 15;89(4):1448-52. PubMed PMID: 1311101; PubMed Central PMCID: PMC48468
95. Borrelli E, Sawchenko PE, Evans RM. Pituitary hyperplasia induced by ectopic
expression of nerve growth factor. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2764-8.
PubMed PMID: 1348359; PubMed Central PMCID: PMC48743 [RESEARCH ARTICLE]
96. Blumberg B, Mangelsdorf DJ, Dyck JA, Bittner DA, Evans RM, De Robertis EM.
Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and
retinoic acid receptors in the Xenopus egg. Proc Natl Acad Sci U S A. 1992 Mar
15;89(6):2321-5. PubMed PMID: 1312717; PubMed Central PMCID: PMC48649
97. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM. Retinoid X receptor interacts
with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature.
1992 Jan 30;355(6359):446-9. PubMed PMID: 1310351 PubMedCentral PMCID:
PMC6159885 [RESEARCH ARTICLE]
98. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C.
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell. 1992 Jan
24;68(2):397-406. PubMed PMID: 1310260. [RESEARCH ARTICLE]
RONALD M. EVANS
99. Oro AE, McKeown M, Evans RM. The Drosophila retinoid X receptor homolog
ultraspiracle functions in both female reproduction and eye morphogenesis. Development.
1992 Jun;115(2):449-62. PubMed PMID: 1330482. [RESEARCH ARTICLE]
100. Oro AE, McKeown M, Evans RM. The Drosophila nuclear receptors: new insight into
the actions of nuclear receptors in development. Curr Opin Genet Dev. 1992 Apr;2(2):269-74.
Review. PubMed PMID: 1638122 [RESEARCH ARTICLE]
101. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A,
Evans RM. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
Genes Dev. 1992 Mar;6(3):329-44. PubMed PMID: 1312497. [RESEARCH ARTICLE]
102. Miller WH Jr, Kakizuka A, Frankel SR, Warrell RP Jr, DeBlasio A, Levine K, Evans
RM, Dmitrovsky E. Reverse transcription polymerase chain reaction for the rearranged
retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute
promyelocytic leukemia. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2694-8. PubMed PMID:
1372989; PubMed Central PMCID: PMC48728. [RESEARCH ARTICLE]
103. Kakizuka A, Sebastian B, Borgmeyer U, Hermans-Borgmeyer I, Bolado J, Hunter T,
Hoekstra MF, Evans RM. A mouse cdc25 homolog is differentially and developmentally
expressed. Genes Dev. 1992 Apr;6(4):578-90. PubMed PMID: 1313771. [RESEARCH
104. Kitabayashi I, Kawakami Z, Chiu R, Ozawa K, Matsuoka T, Toyoshima S, Umesono
K, Evans RM, Gachelin G, Yokoyama K. Transcriptional regulation of the c-jun gene by
retinoic acid and E1A during differentiation of F9 cells. EMBO J. 1992 Jan;11(1):167-75.
PubMed PMID: 1310930; PubMed Central PMCID: PMC556437 [RESEARCH ARTICLE]
105. Cadepond F, Gasc JM, Delahaye F, Jibard N, Schweizer-Groyer G, Segard-Maurel I,
Evans R, Baulieu EE. Hormonal regulation of the nuclear localization signals of the human
glucocorticosteroid receptor. Exp Cell Res. 1992 Jul;201(1):99-108. PubMed PMID: 1612132
106. Ghazal P, DeMattei C, Giulietti E, Kliewer SA, Umesono K, Evans RM. Retinoic acid
receptors initiate induction of the cytomegalovirus enhancer in embryonal cells. Proc Natl
Acad Sci U S A. 1992 Aug 15;89(16):7630-4. PubMed PMID: 1323848; PubMed Central
PMCID: PMC49764 [RESEARCH ARTICLE]
107. Rangarajan PN, Umesono K, Evans RM. Modulation of glucocorticoid receptor
function by protein kinase A. Mol Endocrinol. 1992 Sep;6(9):1451-7. PubMed PMID:
1435789 [RESEARCH ARTICLE]
108. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis
retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation
of their receptors. Nature. 1992 Aug 27;358(6389):771-4. PubMed PMID: 1324435 PMCID:
PMC6159883 [RESEARCH ARTICLE]
RONALD M. EVANS
109. Yao TP, Segraves WA, Oro AE, McKeown M, Evans RM. Drosophila ultraspiracle
modulates ecdysone receptor function via heterodimer formation. Cell. 1992 Oct 2;71(1):63-
72. PubMed PMID: 1327536 [RESEARCH ARTICLE]
110. Tsai S, Bartelmez S, Heyman R, Damm K, Evans R, Collins SJ. A mutated retinoic
acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a
multipotent hematopoietic cell line. Genes Dev. 1992 Dec;6(12A):2258-69. PubMed PMID:
1334022 [RESEARCH ARTICLE]
111. Damm K, Heyman RA, Umesono K, Evans RM. Functional inhibition of retinoic acid
response by dominant negative retinoic acid receptor mutants. Proc Natl Acad Sci U S A.
1993 Apr 1;90(7):2989-93. PubMed PMID: 8096643; PubMed Central PMCID: PMC46222
112. Li E, Sucov HM, Lee KF, Evans RM, Jaenisch R. Normal development and growth of
mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad
Sci U S A. 1993 Feb 15;90(4):1590-4. PubMed PMID: 7679509; PubMed Central PMCID:
PMC45920 [RESEARCH ARTICLE]
113. Lee MS, Kliewer SA, Provencal J, Wright PE, Evans RM. Structure of the retinoid X
receptor alpha DNA binding domain: a helix required for homodimeric DNA binding. Science.
1993 May 21;260(5111):1117-21. PubMed PMID: 8388124 [RESEARCH ARTICLE]
114. Perlmann T, Rangarajan PN, Umesono K, Evans RM. Determinants for selective RAR
and TR recognition of direct repeat HREs. Genes Dev. 1993 Jul;7(7B):1411-22. PubMed
PMID: 8392478 [RESEARCH ARTICLE]
115. Rupprecht R, Arriza JL, Spengler D, Reul JM, Evans RM, Holsboer F, Damm K.
Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to
the glucocorticoid receptor. Mol Endocrinol. 1993 Apr;7(4):597-603. PubMed PMID: 8388999
116. Damm K, Evans RM. Identification of a domain required for oncogenic activity and
transcriptional suppression by v-erbA and thyroid-hormone receptor alpha. Proc Natl Acad
Sci U S A. 1993 Nov 15;90(22):10668-72. PubMed PMID: 7902566; PubMed Central PMCID:
PMC47838 [RESEARCH ARTICLE]
117. Kotomura N, Okada M, Ninomiya Y, Tsukiyama T, Umesono K, Evans RM, Niwa O.
Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. J
Biochem. 1994 Dec;116(6):1309-16. PubMed PMID: 7706222 [RESEARCH ARTICLE]
118. Yao TP, Forman BM, Jiang Z, Cherbas L, Chen JD, McKeown M, Cherbas P, Evans
RM. Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature.
1993 Dec 2;366(6454):476-9. PubMed PMID: 8247157 [RESEARCH ARTICLE]
119. Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM. Chromosomal
localization of the human retinoid X receptors. Genomics. 1994 Apr;20(3):397-403. PubMed
PMID: 8034312 [RESEARCH ARTICLE]
RONALD M. EVANS
120. Dyck JA, Maul GG, Miller WH Jr, Chen JD, Kakizuka A, Evans RM. A novel
macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein.
Cell. 1994 Jan 28;76(2):333-43. PubMed PMID: 8293467 [RESEARCH ARTICLE]
121. Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G. Isoform-specific
amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of
orphan hormone nuclear receptors. Genes Dev. 1994 Mar 1;8(5):538-53. PubMed PMID:
7926749 [RESEARCH ARTICLE]
122. Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM. RXR alpha
mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes
Dev. 1994 May 1;8(9):1007-18. PubMed PMID: 7926783 [RESEARCH ARTICLE]
123. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ,
Umesono K, Evans RM. Differential expression and activation of a family of murine
peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 1994 Jul
19;91(15):7355-9. PubMed PMID: 8041794; PubMed Central PMCID: PMC44398.
124. Forman BM, Chen J, Blumberg B, Kliewer SA, Henshaw R, Ong ES, Evans RM.
Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol
Endocrinol. 1994 Sep;8(9):1253-61. PubMed PMID: 7838158 [RESEARCH ARTICLE]
125. Yu RT, McKeown M, Evans RM, Umesono K. Relationship between Drosophila gap
gene tailless and a vertebrate nuclear receptor Tlx. Nature. 1994 Aug 4;370(6488):375-9.
PubMed PMID: 8047143. [RESEARCH ARTICLE]
126. Lee MS, Sem DS, Kliewer SA, Provencal J, Evans RM, Wright PE. NMR assignments
and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for
the novel C-terminal helix. Eur J Biochem. 1994 Sep 1;224(2):639-50. PubMed PMID:
7925381. [RESEARCH ARTICLE]
127. Kitabayashi I, Chiu R, Umesono K, Evans RM, Gachelin G, Yokoyama K. A novel
pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptormediated trans-activation. In Vitro Cell Dev Biol Anim. 1994 Nov;30A(11):761-8. PubMed
PMID: 7881630 [RESEARCH ARTICLE]
128. Ogura T, Evans RM. A retinoic acid-triggered cascade of HOXB1 gene activation.
Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):387-91. PubMed PMID: 7831296; PubMed
Central PMCID: PMC42745 [RESEARCH ARTICLE]
129. Ogura T, Evans RM. Evidence for two distinct retinoic acid response pathways for
HOXB1 gene regulation. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):392-6. PubMed PMID:
7831297; PubMed Central PMCID: PMC42746 [RESEARCH ARTICLE]
130. Forman BM, Umesono K, Chen J, Evans RM. Unique response pathways are
established by allosteric interactions among nuclear hormone receptors. Cell. 1995 May
19;81(4):541-50. PubMed PMID: 7758108 [RESEARCH ARTICLE]
RONALD M. EVANS
131. Imakado S, Bickenbach JR, Bundman DS, Rothnagel JA, Attar PS, Wang XJ,
Walczak VR, Wisniewski S, Pote J, Gordon JS, et al. Targeting expression of a dominantnegative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of
barrier function. Genes Dev. 1995 Feb 1;9(3):317-29. PubMed PMID: 7867929 [RESEARCH
132. Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka
LT, McMorris T, Lamph WW, Evans RM, Weinberger C. Identification of a nuclear receptor
that is activated by farnesol metabolites. Cell. 1995 Jun 2;81(5):687-93. PubMed PMID:
7774010 [RESEARCH ARTICLE]
133. Dyck JA, Warrell RP Jr, Evans RM, Miller WH Jr. Rapid diagnosis of acute
promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein.
Blood. 1995 Aug 1;86(3):862-7. PubMed PMID: 7620182 [RESEARCH ARTICLE]
134. Schulman IG, Chakravarti D, Juguilon H, Romo A, Evans RM. Interactions between
the retinoid X receptor and a conserved region of the TATA-binding protein mediate
hormone-dependent transactivation. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8288-92.
PubMed PMID: 7667283; PubMed Central PMCID: PMC41142 [RESEARCH ARTICLE]
135. Zhou MD, Sucov HM, Evans RM, Chien KR. Retinoid-dependent pathways suppress
myocardial cell hypertrophy. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7391-5. PubMed
PMID: 7638203; PubMed Central PMCID: PMC41345 [RESEARCH ARTICLE]
136. Rastinejad F, Perlmann T, Evans RM, Sigler PB. Structural determinants of nuclear
receptor assembly on DNA direct repeats. Nature. 1995 May 18;375(6528):203-11. PubMed
PMID: 7746322 [RESEARCH ARTICLE]
137. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. LXR, a
nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 1995 May
1;9(9):1033-45. PubMed PMID: 7744246 [RESEARCH ARTICLE]
138. Dyson E, Sucov HM, Kubalak SW, Schmid-Schönbein GW, DeLano FA, Evans RM,
Ross J Jr, Chien KR. Atrial-like phenotype is associated with embryonic ventricular failure in
retinoid X receptor alpha -/- mice. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7386-90.
PubMed PMID: 7638202; PubMed Central PMCID: PMC41344 [RESEARCH ARTICLE]
139. Zelhof AC, Yao TP, Chen JD, Evans RM, McKeown M. Seven-up inhibits
ultraspiracle-based signaling pathways in vitro and in vivo. Mol Cell Biol. 1995
Dec;15(12):6736-45. PubMed PMID: 8524239; PubMed Central PMCID: PMC230927.
140. Chen JD, Evans RM. A transcriptional co-repressor that interacts with nuclear
hormone receptors. Nature. 1995 Oct 5;377(6548):454-7. PubMed PMID: 7566127
141. Sucov HM, Izpisúa-Belmonte JC, Gañan Y, Evans RM. Mouse embryos lacking RXR
alpha are resistant to retinoic-acid-induced limb defects. Development. 1995
Dec;121(12):3997-4003. PubMed PMID: 8575300 [RESEARCH ARTICLE]
RONALD M. EVANS
142. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxydelta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR
gamma. Cell. 1995 Dec 1;83(5):803-12. PubMed PMID: 8521497 [RESEARCH ARTICLE]
143. Stern CD, Yu RT, Kakizuka A, Kintner CR, Mathews LS, Vale WW, Evans RM,
Umesono K. Activin and its receptors during gastrulation and the later phases of mesoderm
development in the chick embryo. Dev Biol. 1995 Nov;172(1):192-205. PubMed PMID:
758979 [RESEARCH ARTICLE]
144. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg
B, Kastner P, Mark M, Chambon P, Evans RM. The nuclear receptor superfamily: the second
decade. Cell. 1995 Dec 15;83(6):835-9. Review. PubMed PMID: 8521507 PubMed Central
PMCID: PMC6159888 PubMed Central PMCID: PMC6159888 [RESEARCH ARTICLE]
145. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell. 1995
Dec 15;83(6):841-50. Review. PubMed PMID: 8521508 [RESEARCH ARTICLE]
146. Zelhof AC, Yao TP, Evans RM, McKeown M. Identification and characterization of a
Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Proc Natl Acad
Sci U S A. 1995 Nov 7;92(23):10477-81. PubMed PMID: 7479823; PubMed Central PMCID:
PMC40634 [RESEARCH ARTICLE]
147. Doucas V, Ishov AM, Romo A, Juguilon H, Weitzman MD, Evans RM, Maul GG.
Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.
Genes Dev. 1996 Jan 15;10(2):196-207. PubMed PMID: 8566753 [RESEARCH ARTICLE]
148. Ogura T, Alvarez IS, Vogel A, Rodríguez C, Evans RM, Izpisúa Belmonte JC.
Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like
activity. Development. 1996 Feb;122(2):537-42. PubMed PMID: 8625805 [RESEARCH
149. Parker D, Ferreri K, Nakajima T, LaMorte VJ, Evans R, Koerber SC, Hoeger C,
Montminy MR. Phosphorylation of CREB at Ser-133 induces complex formation with CREBbinding protein via a direct mechanism. Mol Cell Biol. 1996 Feb;16(2):694-703. PubMed
PMID: 8552098; PubMed Central PMCID: PMC231049 [RESEARCH ARTICLE]
150. Achkar CC, Derguini F, Blumberg B, Langston A, Levin AA, Speck J, Evans RM,
Bolado J Jr, Nakanishi K, Buck J, Gudas LJ. 4-Oxoretinol, a new natural ligand and
transactivator of the retinoic acid receptors. Proc Natl Acad Sci U S A. 1996 May
14;93(10):4879-84. PubMed PMID: 8643497; PubMed Central PMCID: PMC39373.
151. Blumberg B, Bolado J Jr, Derguini F, Craig AG, Moreno TA, Chakravarti D, Heyman
RA, Buck J, Evans RM. Novel retinoic acid receptor ligands in Xenopus embryos. Proc Natl
Acad Sci U S A. 1996 May 14;93(10):4873-8. PubMed PMID: 8643496; PubMed Central
PMCID: PMC39372 [RESEARCH ARTICLE]
RONALD M. EVANS
152. No D, Yao TP, Evans RM. Ecdysone-inducible gene expression in mammalian cells
and transgenic mice. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3346-51. PubMed PMID:
8622939; PubMed Central PMCID: PMC39610 [RESEARCH ARTICLE]
153. Schulman IG, Evans RM. Retinoid receptors in development and disease. Leukemia.
1997 Apr;11 Suppl 3:376-7. PubMed PMID: 9209395 [RESEARCH ARTICLE]
154. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM.
Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 1996 Apr
15;10(8):974-84. PubMed PMID: 8608944 [RESEARCH ARTICLE]
155. Göttlicher M, Heck S, Doucas V, Wade E, Kullmann M, Cato AC, Evans RM, Herrlich
P. Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor.
Steroids. 1996 Apr;61(4):257-62. PubMed PMID: 8733011 [RESEARCH ARTICLE]
156. Chen JD, Umesono K, Evans RM. SMRT isoforms mediate repression and antirepression of nuclear receptor heterodimers. Proc Natl Acad Sci U S A. 1996 Jul
23;93(15):7567-71. PubMed PMID: 8755515; PubMed Central PMCID: PMC38786
157. Luo J, Sucov HM, Bader JA, Evans RM, Giguère V. Compound mutants for retinoic
acid receptor (RAR) beta and RAR alpha 1 reveal developmental funct
Name : LUCIO I. M. COCCO
Website : https://www.unibo.it/sitoweb/lucio.cocco/en
Address : Cellular Signalling Laboratory, Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy
Tel : +39.051.2091639; +39.338.1194752 (mobile);
EDUCATION : 1976: M.D. University of Chieti (summa cum laude); 1978: Ph.D.- Sport Medicine, University of Chieti, School of Medicine.
1977-1979 : Assistant Professor at the Chair of Anatomy, University of Bologna; 1979-1982: Lecturer of Histology & Embryology, Medical School, University of Chieti, Italy;
1983-1985 : Associate Professor, Department of Anatomy, Medical School, University of Bologna, Italy; 1986-1990: Full Professor and Chairman, Chair of Anatomy, Department of Anatomical Sciences, Medical School, University of Chieti, Italy;
1986-1990 : Director of the Post-Graduate School in Hygiene, Medical School, University of Chieti, Italy;
1990-- : Professor, Cellular Signalling Laboratory, Dept. Biomedical Sciences, Medical School, University of Bologna, Italy;
1992-2018 : Dean of the Research Doctorate Programme in Biomedical Sciences, School of Medicine, University of Bologna, Italy;
2003-2009 : President of the PhD Programme Medical Biotechnology, University of Bologna
2012-- : Professor (visiting by invitation) at the University of Tsukuba, Ph.D. Programme in Human Biology, Japan;
2015-- : Perpetual Secretary of the Academy of Sciences-Physical Sciences of Bologna (founded in 1690);
SCIENTIFIC ACTIVITIES ABROAD
1979-1983 (sabbatical periods) : Visiting Scientist, Beatson Institute for Cancer Research, Glasgow, Scotland, UK;
1986 (sabbatical periods) : Visiting Professor, AFRC Babraham Institute, Cambridge, England, UK;
1992-2010 : President of the Research Evaluation Panel of Biomedical Sciences, University of Bologna;
1994-1997 : Vice-President of the Italian Society for Histochemistry;
1995-2007: President of the Italian Red Cross Nursing School, Bologna;
2003-2006 : Member of the Panel 05 of the Italian CIVR (Italian Research Evaluation Committee);
2009-- : Member of the Evaluation Committee of the Fund for Scientific Research – FNRS, Belgium;
2015- : President of the Research Evaluation Committee of the Department of Biomedical and Neuromotor Sciences of the University of Bologna;
2015-- : Advisory board member of BK21+ Biomolecular Network program, Ulsan National Institute of Science and Technology, S. Korea.
2016-2017 : Member of the Committee (Biomedical Sciences) of Italian Ministry of Research for Programmes of National Interest, Italy
2016 : Member of the panel of Austrian Science Fund for the SFB 'Monarchies and Hierarchies in Shaping Chromatin Landscapes', Austria
2018-2019 : Member of the Committee (Biomedical Sciences) of Italian Ministry of Research for Programmes of National Interest, Italy
2018-2018 : Member of the Academic Senate of the University of Bologna;
2020- : Member of the Evaluation Panel of the University La Sapienza, Rome, Italy
2020- : Member of the Evaluation Committee of the Czech Science Foundation, Czech Republic
2021- : Scientific Curator of the Anatomical Wax Collection of the Museum of the University of Bologna;
2022- : President of the Italian Society for Anatomy and Histology
1996: Intl. J. Oncol. and Oncol. Reps. Award; 2001: Intl. J. Mol. Med. Award.
2012: Brain Poool Programme by S.- Korea Government
2016: Journal Lipid Research Lecturership – FASEB SRC/ASBMB, July/August 2016
2016: Lord Leitchfield Lecturership at the University of Oxford, October 2016
2018: Meet the Expert Award at the 2018 FASEB conference on Phospholipids: Dynamic Lipid Signaling in Health and Disease EDITORIAL BOARD: Editor-in-Chief of Advances in Biological Regulation; Associate Editor of Biochemistry and Cell Biology; Associate Editor Frontiers in Cellular Neuroscience Section Cellular Neuropathology); Associate Editor Biochemistry and Cell Biology; Guest Editor PNAS; Board Member: Cellular Signalling, J. Cellular Biochemistry , European J. Histochem., Oncology Rep. (1996-2003), Leukemia (2011-2013), Intl. J. Oncol., Intl. Arch. Biosci., Intl. J. Mol. Med., Recent Patents on Anti-Cancer Drug Discovery, Am. J. Blood Res., Cancer Rep., World J. Clin. Cases, Journal of Bioenergetics and Biomembranes, International Journal of Molecular Sciences, Netter Atlas of Human Anatomy (Intl. Advisory Board of 6th Edition). MEETINGS SYMPOSIA AND CONFERENCES -Since 1989 he has attended more than 150 international Meetings/Symposia/Conferences (such as FASEB Res. Conf., FEBS Meetings, Gordon Research Conf., Harden Conf., J. Monod Conf.; Eur. Symp. on Hormone&Cell.Regul., Keystone Symp., etc) as invited speaker. -2005: Founder and First Co-Chairman of the series of Gordon Research Conference “Signal Transduction Within the Nucleus”. RESEARCH INTEREST: His work (397 full length papers in peer reviewed Journals including New England Journal of Medicine, Nature, PNAS, J. Biol. Chem., Mol. Cell. Proteomics, FASEB J., Biochem. J., Blood, Leukemia, Stem Cells, J. Clinical Oncology, BBA Reviews on Cancer, Progress in Lipid Research, J. Lipid Research, J. Cell. Physiol, Molecular Psychiatry, EMBO Rep., etc.) covers the following fields: Structure and function of the nucleus and Inositide-dependet Signalling. He has discovered the existence of the nuclear signalling pathway via inositol lipid cycle and he is internationally recognised in the field of inositide signalling as “one the fathers of nuclear inositide signalling” for his seminal work in this issue. In particular since the last years his main interest is the study of the nuclear localisation and signalling activity of polyphosphoinositides. Namely he has furtherd the role of this signalling pathway in the nucleus during myogenic differentiation, giving new insight to its role in myotonic dystrophies, as well as during haemopoietic differentiation, envisaging the pathophysiological significance of nuclear phosphoinositide signalling in pathology. A full list of his articles and updated metrics are available at the Scopus link below: https://www.scopus.com/authid/detail.uri?authorId=7007037315&origin=cto
METRICS from Scopus : Documents: 398; Citations: 14163 h-index: 61
Shin was the founding Director of Brain Science Institute, KIST, and then Director of Center for Cognition and Sociality, IBS. He continues his research as an Honorary Fellow of IBS. He serves a CSO at SL Bigen Co. (Ltd.).
He studied neural mechanisms for animal behaviors, primarily focusing on the role of the thalamus in normal and diseased brains. His interest was on the regulation of intracellular Ca 2+ levels in brain cells. He utilized gene knock-out tools on genes such as voltage-gated Ca 2+ channels and PLC enzymes. Beginning in 2010 his research interest has evolved to neurobiology of social behaviors. He has pioneered to establish a behavioral paradigm, observational fear learning in mice, a rodent model for emotional contagion, basic form of affective empathy. This paradigm allowed, for the first time, to study affective empathy at the molecular and cellular levels.
He has been elected to be a member of the National Academy of Science, Republic of Korea, a foreign member at the National Academy of Science, USA, and an AAAS Fellow.
- Walter Boron biography
- Case Western Reserve University, USA
- The role of membrane proteins as channels for dissolved gases
Dr. Boron is Distinguished University Professor and Myers/Scarpa Professor and Chair of the Department of Physiology & Biophysics at Case Western Reserve University. He earned his AB summa cum laude in chemistry at Saint Louis University, and his MD and PhD (Physiology & Biophysics) at Washington University in St. Louis. Boron joined Yale University as a postdoctoral fellow with Emile Boulpaep in 1978, and remained there for the next 29 years, serving three terms as Chairman of the Department of Cellular & Molecular Physiology. In 2007, he returned to his hometown of Cleveland to assume his present position.
Boron developed his life-long interest in acid-base transport and intracellular-pH (pHi) regulation during his PhD studies with Albert Roos (his official mentor), Paul De Weer, and John Russell; and his interest in renal HCO3−transport with postdoctoral mentor Boulpaep. Boron and collaborators described the first example of dynamic pHi regulation, discovered the electrogenic Na/HCO3 cotransporter (NBCe1), and introduced many of the paradigms used to study pHi regulation. The cloning, by the Boron Lab, of the cDNA encoding NBCe1 led to the identification of numerous, related HCO3−transporters. Their invention of out-of-equilibrium CO2/HCO3− solutions led to the discovery of receptor protein tyrosine phosphatase γ (RPTPγ) as a molecular sensor of extracellular CO2 and HCO3−, and modulator of acid-base transport. Their encounter with the first CO2-impermeable membrane led to the discovery of the first example of a membrane protein with permeability to a dissolved gas, aquaporin-1. Boron’s group currently focuses on three related areas: the molecular physiology of the Na+-coupled HCO3−transporters, RPTPγ and RPTPζ, as well as CO2 and O2 channels.
Boron is former President of the American Physiological Society (APS) and former Secretary General of the International Union of Physiological Sciences (IUPS), as well as former editor in-chief of two journals, Physiological Reviews and Physiology. He is currently chair of the IUPS Publications Committee. Boron and Emile Boulpaep co-edit the textbooks Medical Physiology and Concise Medical Physiology.
Among Boron’s accolades are the Pitts Lecture/Award (IUPS, 1993), Gottschalk Lecture/Award (APS, 1998), NIH MERIT Award (2002), an honorary doctorate (Aarhus University, 2014), National Academy of Medicine (USA, 2014), Fellow of the APS (2015), and Fenn Lecture (IUPS, 2022).
- Mario Delmar biography
- NYU School of Medicine, USA
- Molecular mechanisms of sudden cardiac arrest in young athletes: The case of ARVC.
Mario Delmar, MD,PhD is the Patricia M. and Robert H. Martinsen Professor of Cardiology at New York University School of Medicine.
Mario Delmar was born and raised in Mexico City. He obtained his MD from the Metropolitan University (Universidad Autonoma Metropolitana) in Mexico City in 1980. He began his PhD studies at the National Polytechnic Institute (Instituto Politecnico Nacional; Centro de Investigacion y Estudios Avanzados) in Mexico under the advice of Dr. Carlos Mendez and completed them in 1986 under the advice of Dr. Jose Jalife, at the State University of New York (SUNY) in Syracuse.
In 1988, Dr. Delmar joined the Faculty at SUNY-Syracuse as Assistant Professor, was promoted to Associate Professor with Tenure in 1993 and to full Professor in 1998. In 2008 he joined the University of Michigan as the Frank N Wilson Professor of Cardiology and Co-Director of the Center for Arrhythmia Research. In 2010 he moved to New York University as Professor of Medicine with Tenure and in 2015 he received the Martinsen Endowed Chair and was named the Patricia M. and Robert H. Martinsen Professor of Cardiology.
Dr. Delmar has published over 170 papers (h index: 65; more than 12,000 citations), and his research has been supported by NIH, without interruption, since 1988 (more than 30 years of continuous NIH funding). At present, Dr. Delmar is Principal Investigator in one NIH-RO1, is the North American Coordinator of a Leducq Transatlantic Network of Excellence (Prof. Connie Bezzina, European Coordinator) and is the recipient of an R35 Outstanding Investigator Award from NIH-NHLBI (2022-2027).
Through the years, Dr. Delmar has trained more than 30 post-doctoral fellows and 20 graduate students. Trainees in the Delmar lab have received multiple awards while in training, including Fellowships from NASPE (1995, 2003), HRS (2005, 2013, 2014, 2016, 2019, 2020) and AHA (1996, 1997, 2005, 2006, 2007, 2010, 2015, 2109, 2021), recognitions for “Best paper of the Year” in Heart Rhythm (2005, 2012) and in Cardiovascular Research (2017), and several Young Investigator Awards including the SADS Foundation Young investigator Award in Basic Sciences (2019, 2022).
Dr. Delmar has served and continuous to serve the Heart Rhythm Society and the American Heart Association in several capacities, most recently as member of the Program Committee for the HRS scientific sessions (2014-2019) and team leader of the basic/translational science subcommittee (2019), as a member of the HRS Research Committee (2019-2021) and as a member of the Oversight Advisory Committee for the Arrhythmia and Sudden Cardiac Death Strategically Focused Network of the American Heart Association (2019-present). He also served as President of the Cardiac Electrophysiology Society (2018-2020).
Dr. Delmar has served in multiple NIH study sections, beginning in 1997, and most recently as a member of the Electrical Signaling, Ion Transport and Arrhythmias (ESTA) Study Section of the NIH (2017-2021) and as Chair of the MPPB Study Section (2021-2023). He is also a frequent ad hoc grant reviewer for several European organizations including the Medical Research Council (UK), the European Research Council, the European Commission, and the Dutch Heart Foundation (NL).
Dr. Delmar served as Associate Editor of the Am J Physiol (Heart Circ. Physiol.), and is an Editorial Board member for Circulation Research and for Heart Rhythm Journal, as well as a frequent reviewer for high impact journals.
Dr. Delmar has received multiple honors including being named the Giovanni Battista Morgagni Lecturer of University of Padova (2011), the Keynote Speaker of the International Gap Junctions Conference (2011), the Gordon K Moe lecturer for the Cardiac Electrophysiology Society Annual meeting (in 2016), and the Michel Mirowski MD Lecturer in Cardiology at Johns Hopkins School of Medicine. The work of his laboratory has been recognized three times with the “Basic Research Prize” granted by The Zurich Heart House to the best published paper in ARVC (2016, 2019, 2022). Most recently, Dr. Delmar was honored by the Heart Rhtyhm Society by conferring to him the 2020 Distinguished Scientist Award, and by the National Institutes of Health with an R35 Outstanding Investigator Award (2022).
Dr. Delmar has been a Visiting Professor at University of Utrecht, NL and most recently, at University of Copenhagen, DK (2020-2021). He is an Elected Fellow of the American Heart Association, an Elected Fellow of the Heart Rhythm Society and an Elected Founding Member of the European Cardiac Arrhythmia Society; his research interest is on the cellular/molecular mechanisms leading to sudden cardiac death in inheritable arrhythmia syndromes, with a primary focus on arrhythmogenic right ventricular cardiomyopathy (ARVC).
- Nabekura Junichi biography
- National Institute for Physiological Sciences, Japan
- From passive “glue” to dynamic renovators: Active surveillance and remodelling of neuronal circuits by microglia and astrocytes.
National Institute for Physiological Sciences 38 Myodaiji, Okazaki, Aichi,444-8585, Japan
1981 Graduation, School of Medicine, Kyushu University, Fukuoka, Japan
1986 Ph.D; Graduate School of Medical Sciences. Kyushu University, Fukuoka, Japan
1986-1989 Research Associate, School of Medicine, Washington University, St. Louis USA
1990-1992 Assistant Professor, Tohoku University School of Medicine, Sendai, Japan
1992-1994 Associate Professor, Akita University School of Medicine, Akita, Japan
1994-2003 Associate Professor, Kyushu University School of Medicine, Fukuoka, Japan
2003-2019 Professor, Division of Homeostatic Development, National Institute for Physiological Sciences (NIPS)
2019- Director General, National Institute for Physiological Sciences
Out-side of NIPS
2019 President 9 th Congress of Federation of Asian Oceanian Physiological Sciences (FAOPS)
- Gou Young Koh biography
- Center for Vascular Research, Institute for Basic Science/KAIST, Korea
- Exploring Novel Lymphatics for Brain Clearance
Gou Young Koh, M.D., Ph.D.
Director, Center for Vascular Research, IBS
Distinguished Professor, KAIST
Scientific Member, Max Plank Institute
Gou Young Koh is a distinguished professor at KAIST Graduate School of Medical Science and Engineering, and the director of the Center for Vascular Research, Institute for Basic Science. He is also an external member of Max-Plank Institute. For the last 25 years, he has focused on the discovery and understanding of the growth factors regulating micro-vasculatures including tumor vasculature. During this time, his research team has made numerous major advances and breakthroughs in the field of angiogenesis and lymphangiogenesis. Notably, he and his research team discovered and generated several novel and potent modulators of angiogenesis – three angiopoietin-like proteins, COMP-Ang1, DAAP and ABTAA – based on their keen observations and creative ideas. Moreover, he and his team have made ground-breaking discoveries in the understanding of the unique features and regulations of tumor vessels as well as on the characterization of key factors involved in organotypic angiogenesis and vascular maintenance. Lately, they have performed landmark studies in uncovering critical regulators for maintaining the integrity of specialized lymphatic vessels such as meningeal lymphatic vessels. By recognition of his outstanding and excellent achievements and contributions to biomedical communities, he became laureates of the Kyung-Am Prize (2011), Asan Award in Medicine (2012), and Ho-Am Prize in Medicine (2018).
- Armin Kurtz biography
- Universität Regensburg, Germany
- Endo- and paracrine functions of the kidney interstitium
CV Armin Kurtz, MD
Date and place of birth
January 7,1955 in Straubing, Germany
married, 3 children
Physiologisches Institut, Universität Regensburg,Universitätsstraße 31, D-93053 Regensburg
1974-1980 study of medicine at universities of Regensburg and Munich, Germany
1980 medical exam
1982 MD thesis „Functional properties of isolated hemoglobin subunits“ at University of Regensburg
1981-1984 Research fellow and Postdoc at the Institute of Physiology of University of Regensburg, Germany
1984-1987 Postdoc in the lab of Christian Bauer at the Institute of Physiology of University of Zurich, Swtzld
1988 Postdoc in the lab of Erwin Neher at the Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany
1988 Habilitation for Physiology at the University of Zürich
1989-1991 Lecturer, Institute of Physiology University of Zürich, Swtzld
since 1991 Full Professor and Chair of Physiology, University of Regensburg, Germany
1999-2001 Dean of the Faculty of Biology and Preclinical Medicine, University of Regensburg
2004-2009 Vice-president for Research, University of Regensburg
Honors and merits:
1982 Bavarian award for excellent MD thesis (EoN-Prize)
1987 Volhard- Prize of German Society of Nephrology
1988 research fellowship of Max-Planck-Society
2004-2009 Secretary General of German Society of Nephrology
since 2006 Member of German Academy of Science (Leopoldina)
2006-2017 organizer and spokesman of the DFG funded collaborative research center (SFB 699) “structural, functional and molecular determinants of the kidney”
2007-2016 Member of the DFG study section Physiology
2010 Franz Gross Prize of German Hypertension Society
2010-2011 President of German Physiological Society
2013 Franz Volhard Medal of German Society of Nephrology
since 2016 Senator of German Academy of Science (Leopoldina)
2019 Honorary doctorate Syddansk University at Odense, Denmark
European Journal of Physiology (since 2106 editor in chief)
American Journal of Physiology
Kidney and Blood Pressure Research
Fields of research:
Kidney function, blood pressure regulation, RAAS, erythropoietin
- Robyn Murphy biography
- La Trobe University, Australia
- Cellular specific abundance of dysferlin in skeletal muscle
Robyn Murphy is the Deputy Dean and Associate Dean, Learning and Teaching in the School of Agriculture, Biomedicine and Environment at La Trobe University, Melbourne, Australia. She is the President of the Australian Physiological Society and is the Secretary for the International Research Group on Biochemistry of Exercise. Robyn has published over 105 peer-reviewed research articles.
The overall research interest of the Murphy lab is skeletal muscle in health and disease, from a muscle biochemistry perspective. Using very small sample sizes of segments of individual skeletal muscle fibres, proteins important for metabolic and overall muscle health are examined. Robyn has been interested in understanding muscular dystrophies and in recent times, has focused on dysferlin to unravel the disease manifestation in its absence.
- Uhtaek Oh biography
- KIST, Korea
- Tentonin 3, a novel mechanosensitive channel with slow inactivation kinetics: its biophysical property and physiological functions
2022 ~ present: Principal Researcher, Brain Science Institute, KIST
2017 ~ 2021: Institute Director, Brain Science Institute, KIST
1988 ~ 2016: Professor, Seoul National University, College of Pharmacy
SNU (B.S.) – U Oklahoma (Ph.D.) – U Texas (postdoc)
Discovery of novel channels for mechanotransduction and other functions
(Anoctamins/TMEM16 and Tentonins/TMEM150)
> Honors and Awards:
2006 National Academy of Science Award of Korea (學術院賞)
2010 The Best Scientist and Engineer Award of Korea (Presidential Award)
2019 Ho-Am Prize for Medicine
- David Paterson biography
- Oxford University, United Kingdom
- Disease in a Dish using hiPSC : Transcriptional and Signal Transduction Underlying Neuromodulation of Heart Rhythm
David Paterson is New Zealand born British physiologist and academic having been a graduate from the University Otago in NZ, University of Western Australia, and University of Oxford. He is Head of the Department of Physiology, Anatomy & Genetics (QS World ranked 1st last three years) at Oxford and Professor of Physiology, and Fellow of Merton College.
Currently President of The Physiological Society of the United Kingdom and Republic of Ireland and a past Editor-in-Chief of The Journal of Physiology.
He is best known for his work in cardiac neurobiology, linking the nervous system to heart rhythm, which featured in the 2012 BBC4 documentary Heart v Mind What makes us Human?
He is a Honorary Fellow of the Royal Society of New Zealand, Fellow of The American Physiological Society, The Physiological Society and Royal Society of Biology.
- Edward Schuchman biography
- Mount Sinai Medical Center, USA
- Lipid Metabolizing Enzymes & Therapy: Experiences From Acid Sphingomyelinase & Acid Ceramidase
Dr. Schuchman is the Genetic Disease Foundation – Francis Crick Professor of Genetics & Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York. He has been on the faculty at Mount Sinai for over 35 years, where his laboratory studies drug discovery and development for rare diseases. His specific area of research focuses on the lysosomal storage diseases, and he is responsible for the first isolation and characterization of several genes encoding the lysosomal enzymes deficient in these diseases, including acid sphingomyelinase (ASM), deficient in types A and B Niemann-Pick disease, acid ceramidase (AC), deficient in Farber lipogranulomatosis, and N-acetylgalactosamine 4-sulfatase, deficient in mucopolysaccharidosis type VI (Maroteaux-Lamy disease). His laboratory also identified the first genetic abnormalities and developed the first animal models for these diseases, and evaluated various approaches to treatment, including enzyme, gene and small molecule therapies. One of these therapies, for types A and B Niemann-Pick disease (Xenpozyme®), recently received global regulatory approval and is being used to treat patients throughout the world. Several other drugs are in various stages of clinical or preclinical development. His research has been continuously funded by the National Institutes of Health and other grant agencies for nearly 40 years, has led to the publication of over 250 peer-reviewed articles and 50 book chapters and numerous awards, and he has delivered over 500 invited lectures in over 30 countries describing his research.
- Shaw-Jenq Tsai biography
- National Cheng Kung University, Taiwan
- Pathophysiological functions of dual specificity phosphatase-2 in human diseases
Chair Professor and Director, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Taiwan.
Academy Fellow, International Union of Physiological Sciences
-Director, Center for Bioinformatics and Digital Health, National Cheng Kung University
- Ambassador, World Endometriosis Society
- Councilor, Society of Experimental Biology and Medicine
Professor Shaw-Jenq (Sean) Tsai received his PhD degree from the University of Wisconsin-Madison, USA in 1997. He then joined the Department of Physiology at the National Cheng Kung University, Taiwan, as an assistant professor in 1998. He was promoted to Distinguished professor in 2008 and Chair professor in 2019 in recognition of his great academic achievements. Professor Tsai also served as the Director-General of Department of Life Sciences, Ministry of Science and Technology, Taiwan from 2014 to 2017. He was the past president of Chinese Physiological Society and Asian Society of Endometriosis and Adenomyosis.
Professor Tsai’s research focuses on investigating molecular mechanisms underlying important human diseases including cancer, polycystic ovarian syndrome, and endometriosis. He has published more than 140 papers in prestigious journals such as Nature, Nature Communications, Journal of Clinical Investigation, Journal of Pathology, Cancer Research, Clinical Cancer Research, Nucleic Acids Research, and PNAS. His papers had been cited more than 8500 times with an H-index of 51.
Owing to his great contribution in endometriosis research, Professor Tsai was appointed as Ambassador of World Endometriosis Society in 2012. Professor Tsai was awarded as the “2014 Distinguished Scientist” by Society for Experimental Biology and Medicine and “2021 Fuller W. Bazer SSR International Scientist Award” by Society for the Study of Reproduction. In 2022, Professor Tsai was elected to the Academy of International Union of Physiological Sciences as a fellow. Professor Tsai serves as an editorial board member of many journals and is currently the senior editor of Journal of Endocrinology and Journal of Molecular Endocrinology. He is also the Asian editor of Experimental Biology and Medicine.
- Tian Xue
- University of Science & Technology of China (USTC), China
- Light and Life – Not Just for Seeing
- Noriyuki Koibuchi biography
- Gunma University Graduate School of Medicine, Japan
- Educating Humanities in Physiology Education
Dr. Noriyuki Koibuchi, M.D., Ph.D. is currently serving as a Chair of Education Commission of FAOPS. He was also a President of the FAOPS2019 and ADInstruments Teaching Workshop that was held in conjunction with FAOPS2019 at Kobe, Japan.
He graduated Gunma University School of Medicine for his M.D. degree and obtained Ph.D. at the Institute of Endocrinology, Gunma University. After serving as a postdoctoral fellow at the Rockefeller University, he appointed as an Assistant Professor of Physiology at the Dokkyo University School of Medicine, followed by a Visiting Assistant Professor at the Harvard Medical School. Then, he became a Professor of Integrative Physiology, Gunma University Graduate School of Medicine, in 2001. In addition to his career as a researcher in the field of Endocrine Physiology, he has devoted himself into education. He integrated team-based learning (TBL) using clinical cases into Physiology class, through which learners can learn not only the concept of Physiology and Pathophysiology, but also humanities that is required medical professionals. He will introduce his experience in Physiology education through his talk.